{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:58:03Z","timestamp":1785437883298,"version":"3.56.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To compare retinal nerve fiber layer (RNFL) thickness, ganglion cell complex (GCC) thickness, and visual field parameters in patients with sellar and parasellar brain tumors and to evaluate their associations with tumor size.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This hospital-based cross-sectional comparative study was conducted over 18 months at a tertiary care center. Patients aged 12\u201360 years with magnetic resonance imaging (MRI)-confirmed sellar or parasellar tumors underwent best-corrected visual acuity assessment, automated perimetry (Humphrey 30-2), and spectral-domain optical coherence tomography for RNFL and GCC analysis. Tumor size was recorded from MRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Sixty-seven patients (31 sellar, 36 parasellar) were analyzed. Superior quadrant RNFL thickness in the right eye was significantly reduced in sellar tumors (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.029). Parasellar tumors were significantly larger in size (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Tumor size showed significant associations with visual acuity and visual field indices in sellar tumors but not in parasellar tumors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Sellar tumors were associated with more consistent structural and functional visual impairment compared with parasellar tumors despite a smaller mean tumour size likely due to early chiasmal compression. RNFL thinning on optical coherence tomography may reflect early structural involvement of the optic pathway and may complement automated perimetry and neuroimaging in clinical evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_215_26","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:00:15Z","timestamp":1785434415000},"page":"1185-1190","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Effect of sellar and parasellar brain tumors on retinal thickness and visual fields: A cross-sectional comparative study"],"prefix":"10.4103","volume":"74","author":[{"given":"Harika D","family":"Kasireddy","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya","family":"Sahu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aseem","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Shrivastava","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"R1-20260730","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/sj.eye.6701592","article-title":"Primary tumours of the optic nerve and its sheath","volume":"18","author":"Miller","year":"2004","journal-title":"Eye (Lond)"},{"key":"R2-20260730","first-page":"70","article-title":"Pituitary adenomas: Clinical presentation and management","volume":"70","author":"Laws","year":"2012","journal-title":"Neurosurgery"},{"key":"R3-20260730","first-page":"89","article-title":"Meningiomas of the optic canal","volume":"26","author":"Al-Mefty","year":"1990","journal-title":"Neurosurgery"},{"key":"R4-20260730","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0039-6257(92)90135-G","article-title":"Optic nerve sheath meningiomas","volume":"37","author":"Dutton","year":"1992","journal-title":"Surv Ophthalmol"},{"key":"R5-20260730","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1210\/er.2013-1115","article-title":"Craniopharyngioma","volume":"35","author":"M\u00fcller","year":"2014","journal-title":"Endocr Rev"},{"key":"R6-20260730","first-page":"1045","article-title":"Atrophy of retinal ganglion cells after lesions of the optic tract","volume":"14","author":"Cowey","year":"1974","journal-title":"Vision Res"},{"key":"R7-20260730","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1093\/brain\/awp001","article-title":"Retrograde trans-synaptic retinal ganglion cell loss identified by optical coherence tomography","volume":"132","author":"Jindahra","year":"2009","journal-title":"Brain"},{"key":"R8-20260730","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10143-016-0772-1","article-title":"Optical coherence tomography impacts the evaluation of visual pathway tumours","volume":"41","author":"Banc","year":"2018","journal-title":"Neurosurg Rev"},{"key":"R9-20260730","first-page":"890","article-title":"Using retinal nerve fiber layer thickness to monitor axonal loss in optic neuropathies","volume":"67","author":"Costello","year":"2006","journal-title":"Neurology"},{"key":"R10-20260730","first-page":"1085","article-title":"In vivo retinal nerve fiber layer thickness measurement correlates with visual field loss in optic neuropathies","volume":"115","author":"Danesh-Meyer","year":"2008","journal-title":"Ophthalmology"},{"key":"R11-20260730","first-page":"220","article-title":"Evaluation of retinal nerve fiber layer and macular thickness in chiasmal compression","volume":"55","author":"Monteiro","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R12-20260730","first-page":"2336","article-title":"Ganglion cell\u2013inner plexiform layer thickness in compressive optic neuropathy","volume":"118","author":"Moon","year":"2011","journal-title":"Ophthalmology"},{"key":"R13-20260730","first-page":"1287","article-title":"Criteria for early detection of visual impairment in pituitary adenoma","volume":"55","author":"Fujimoto","year":"2004","journal-title":"Neurosurgery"},{"key":"R14-20260730","first-page":"417","article-title":"MRI predictors of visual dysfunction in sellar and parasellar lesions","volume":"129","author":"Jacob","year":"2018","journal-title":"J Neurosurg"},{"key":"R15-20260730","first-page":"2150","article-title":"Relationship between retinal nerve fiber layer thickness and visual field sensitivity in compressive optic neuropathy","volume":"113","author":"Danesh-Meyer","year":"2006","journal-title":"Ophthalmology"},{"key":"R16-20260730","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/ana.20851","article-title":"Quantifying axonal loss after optic neuritis with optical coherence tomography","volume":"59","author":"Costello","year":"2006","journal-title":"Ann Neurol"},{"key":"R17-20260730","first-page":"1517","article-title":"Early detection of optic chiasmal compression using ganglion cell\u2013inner plexiform layer analysis","volume":"121","author":"Moon","year":"2014","journal-title":"Ophthalmology"},{"key":"R18-20260730","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/WNO.0000000000000424","article-title":"Ganglion cell complex loss in chiasmal compression by pituitary adenoma","volume":"37","author":"Tieger","year":"2017","journal-title":"J Neuroophthalmol"},{"key":"R19-20260730","first-page":"355","article-title":"Optical coherence tomography in compressive optic neuropathy","volume":"39","author":"Blanch","year":"2019","journal-title":"J Neuroophthalmol"},{"key":"R20-20260730","first-page":"1623","article-title":"Macular ganglion cell layer thinning in patients with chiasmal compression","volume":"9","author":"Monteiro","year":"2015","journal-title":"Clin Ophthalmol"},{"key":"R21-20260730","first-page":"21","article-title":"Retinal nerve fiber layer loss in pituitary adenoma\u2013related chiasmal compression","volume":"181","author":"Garcia","year":"2017","journal-title":"Am J Ophthalmol"},{"key":"R22-20260730","first-page":"1194","article-title":"Visual outcome after transsphenoidal surgery for pituitary adenomas","volume":"61","author":"Fujimoto","year":"2007","journal-title":"Neurosurgery"},{"key":"R23-20260730","first-page":"302","article-title":"Relationship between pituitary adenoma size and retinal nerve fiber layer thickness","volume":"20","author":"Qin","year":"2020","journal-title":"BMC Ophthalmol"},{"key":"R24-20260730","first-page":"1113","article-title":"Clinical features and management of optic nerve sheath meningioma","volume":"102","author":"Dutton","year":"1995","journal-title":"Ophthalmology"},{"key":"R25-20260730","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/0090-3019(88)90200-5","article-title":"Surgery of tumors invading the cavernous sinus","volume":"30","author":"Al-Mefty","year":"1988","journal-title":"Surg Neurol"},{"key":"R26-20260730","first-page":"456","article-title":"Visual dysfunction in parasellar lesions: MRI correlations","volume":"64","author":"Jacob","year":"2016","journal-title":"Neurol India"},{"key":"R27-20260730","doi-asserted-by":"crossref","first-page":"717","DOI":"10.3171\/jns.1977.46.6.0717","article-title":"Transsphenoidal decompression of pituitary adenomas: Visual results","volume":"46","author":"Laws","year":"1977","journal-title":"J Neurosurg"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_215_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:00:40Z","timestamp":1785434440000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_215_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_215_26","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,31]]},"assertion":[{"value":"2026-01-22","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-27","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}