{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:24:36Z","timestamp":1787765076725,"version":"build-2784847793"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To describe disease characteristics and outcomes of Vogt\u2013Koyanagi\u2013Harada (VKH) disease in elderly patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Retrospective analysis of patients older than 50 years with VKH disease at two referral centers in India. Demographics, extraocular and ocular involvement, treatment, complications, and visual acuity outcomes were noted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In total, 69 patients (mean age at presentation: 56.4 \u00b1 4.7 years) were analyzed; 6\/69 patients had diabetes mellitus at presentation, and 10\/69 had hypertension. Clinical signs included anterior chamber cells &gt;2+ (29%), granulomatous keratic precipitates (23%), disc hyperemia (26%), neurosensory retinal detachment (34.7%), and \u201csunset-glow\u201d fundus (52.1%). Patients were classified as probable (n = 50, 72.4%), incomplete (n = 18, 26%), and complete VKH (n = 1, 1.4%). The mean follow-up period was 20.2 \u00b1 19.4 months. Improvement in mean BCVA of (0.63 LogMAR, 6 Snellen lines) was noted on the last follow-up. Patients receiving systemic steroids with immunosuppressants (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001) had better visual outcomes at final follow-up compared to steroids alone (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.103). Eight patients (11.6%) had complications due to systemic immunosuppressants, and 17 patients (24.6%) developed diabetes mellitus or had worsening of diabetes while on systemic corticosteroids.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Few patients presented with systemic manifestations in our cohort. Those treated with steroids and concurrent immunosuppressants had better outcomes. However, therapy with immunosuppressants was encountered with major dose-limiting complications in a significant number of elderly patients with VKH syndrome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2185_23","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T10:01:00Z","timestamp":1704708060000},"page":"S580-S583","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["VKH disease in the elderly: Variations in clinical course as compared to VKH disease in adults"],"prefix":"10.4103","volume":"72","author":[{"given":"Hrishikesh","family":"Kaza","sequence":"first","affiliation":[{"name":"Uveitis and Retina Services, MTC Campus, L V Prasad Eye Institute, Bhubaneshwar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navya","family":"Cherukuri","sequence":"additional","affiliation":[{"name":"Uveitis and Ocular Immunology Services, Smt Kanuri Santhamma Center for Vitreo-Retina Diseases, L. V. Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mudit","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Uveitis and Ocular Immunology Services, Smt Kanuri Santhamma Center for Vitreo-Retina Diseases, L. V. Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumyava","family":"Basu","sequence":"additional","affiliation":[{"name":"Uveitis and Retina Services, MTC Campus, L V Prasad Eye Institute, Bhubaneshwar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev R","family":"Pappuru","sequence":"additional","affiliation":[{"name":"Uveitis and Ocular Immunology Services, Smt Kanuri Santhamma Center for Vitreo-Retina Diseases, L. V. 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