{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:18:51Z","timestamp":1787847531994,"version":"build-2784847793"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,4]]},"abstract":"\n Purpose:<\/jats:title>\n To evaluate the outcomes of keratoplasty for xeroderma pigmentosum (XP) performed at a tertiary eye care center.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A retrospective review of medical records of those patients who were clinically diagnosed to have XP (54 eyes of 36 patients) and underwent keratoplasty; either deep anterior lamellar keratoplasty (DALK, four eyes), endothelial keratoplasty (EK, eight eyes), or penetrating keratoplasty (PK, 42 eyes) from 1994 to 2018.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The median age at surgery was 20.6 years (interquartile range [IQR], 14.6\u201327.6 years) and 20 (55.6%) were males. Graft failure occurred in 15 eyes (35.7%) in the PK group and two eyes (50%) in the DALK group; none failed in the EK group. The probability of graft survival in the PK group was 97.2% \u00b1 2.7% at 1 year, 74.0% \u00b1 8.0% at 2 years, and 54.8% \u00b1 11.7% at 5 years. In the PK group, 13 eyes needed antiglaucoma medications, 11 eyes developed graft infiltrate, and 13 eyes needed secondary interventions (cataract surgery, excision biopsy, and tarsorrhaphy). In the EK group, three eyes needed secondary interventions (excision biopsy). Median postoperative endothelial cell density at the last follow-up in the PK group was 1214 cells\/mm\n 2<\/jats:sup>\n (IQR, 623\u20132277 cells\/mm\n 2<\/jats:sup>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Despite the complexities of the ocular surface and adnexal issues in XP, keratoplasty had reasonably good outcomes. More than half of the PK grafts survived 5 years with no failures in the EK group. Regular follow-up and timely management of suture-related infections raised intraocular pressure, and suspicious ocular surface lesions, in addition to solar protection, are important for the success of keratoplasty in these eyes.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2188_20","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T05:15:35Z","timestamp":1615958135000},"page":"860-864","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Outcomes of keratoplasty in a cohort of Indian patients with xeroderma pigmentosum"],"prefix":"10.4103","volume":"69","author":[{"given":"Shravya Sri","family":"Durgam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashik","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muralidhar","family":"Ramappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Chaurasia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-17-20240828","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/S0161-6420(82)34692-8","article-title":"Ocular involvement in Xeroderma pigmentosum","volume":"89","author":"Gasterland","year":"1982","journal-title":"Ophthalmology"},{"key":"R2-17-20240828","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00003226-199203000-00014","article-title":"Management of Corneal complications in Xeroderma 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