{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:40:12Z","timestamp":1786650012352,"version":"build-2736575974"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>The Reper device (Reper-NN LTD, Nizhny Novgorod, Russia), an acrylic iris diaphragm combined with an intraocular lens (IOL), may be adapted for patients with various iris defects and aphakia. We aim to present our experience using the Reper artificial iris-IOL device.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Tertiary medical center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study includes patients who underwent implantation of the Reper artificial iris-IOL device at a single tertiary medical center between 2017 and 2023. The non-parametric signed test was used to compare preoperative and postoperative outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Fifteen patients with aphakia and partial aniridia were included (four females [27%], mean age: 68.3). Mean follow-up time was 7.87 \u00b1 5.62 months (range: 1\u201320). Following surgery, 87% (13 patients) showed improvement in corrected distance visual acuity (CDVA), while 13% (two patients) maintained their preoperative CDVA. The mean improvement in CDVA was 0.68 \u00b1 0.19 logMAR (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value = 0.0015 [95% confidence interval (CI): 0.28\u20131.08. Unpaired\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test]). Moreover, all patients (100%) expressed complete satisfaction with postoperative cosmetic outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study represents the largest reported series on Reper artificial iris-IOL implantation procedure and provides initial insights into its outcomes. No surgical complications were reported, and most patients experienced VA improvement and cosmetic satisfaction. These findings may assist ophthalmic surgeons in evaluating the benefits and risks of this implant. Larger, longer-term studies are needed to better establish its safety and efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_218_25","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T15:00:25Z","timestamp":1767020425000},"page":"59-64","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Reper intraocular lens with artificial iris: Presentation and outcomes in patients with significant iris defects and Aphakia"],"prefix":"10.4103","volume":"74","author":[{"given":"Nir","family":"Gomel","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Tel Aviv Sourasky Medical Center and School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadav","family":"Shemesh","sequence":"additional","affiliation":[{"name":"The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel"},{"name":"Department of Ophthalmology, Hadassah Medical Center, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itai","family":"Lavi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hadassah Medical Center, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asaf","family":"Achiron","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tel Aviv Sourasky Medical Center and School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mimouni","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Rambam Health Care Campus Affiliated with the Technion-Israel Institute of Technology, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Sorkin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tel Aviv Sourasky Medical Center and School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tel Aviv Sourasky Medical Center and School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Verssano","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tel Aviv Sourasky Medical Center and School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliya","family":"Levinger","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tel Aviv Sourasky Medical Center and School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"R1-20260420","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/ejhg.2012.100","article-title":"Aniridia","volume":"20","author":"Hingorani","year":"2012","journal-title":"Eur J Hum Genet"},{"key":"R2-20260420","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/IIO.0b013e318169314b","article-title":"Aniridia","volume":"48","author":"Brauner","year":"2008","journal-title":"Int Ophthalmol Clin"},{"key":"R3-20260420","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.jcrs.2016.03.035","article-title":"Outcomes of implantation of modified capsule tension rings with multiple black occluder paddles for eyes with congenital and acquired iris defects: Report 3","volume":"42","author":"Miller","year":"2016","journal-title":"J Cataract Refract Surg"},{"key":"R5-20260420","doi-asserted-by":"crossref","first-page":"100673","DOI":"10.1016\/j.ajoc.2020.100673","article-title":"Implantation of a small-aperture intraocular lens and a partial aniridia implant in eyes with traumatic iris defects","volume":"18","author":"Son","year":"2020","journal-title":"Am J Ophthalmol Case Rep"},{"key":"R6-20260420","doi-asserted-by":"crossref","first-page":"e924706-1","DOI":"10.12659\/AJCR.924706","article-title":"Traumatic aniridia and aphakia management with iris reconstruction lens using gore-tex sutures, an ab-externo approach","volume":"21","author":"Parikakis","year":"2020","journal-title":"Am J Case Rep"},{"key":"R7-20260420","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1001\/archophthalmol.2011.1778","article-title":"A new technique for treating posttraumatic aniridia with aphakia: First results of haptic fixation of a foldable intraocular lens on a foldable and custom-tailored iris prosthesis","volume":"130","author":"Spitzer","year":"2012","journal-title":"Arch Ophthalmol"},{"key":"R8-20260420","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1186\/s12886-020-01621-8","article-title":"Functional outcomes after combined iris and intraocular lens implantation in various iris and lens defects","volume":"20","author":"Mayer","year":"2020","journal-title":"BMC Ophthalmol"},{"key":"R9-20260420","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ajo.2020.03.036","article-title":"Safety and efficacy of colored iris reconstruction lens implantation","volume":"216","author":"Wang","year":"2020","journal-title":"Am J Ophthalmol"},{"key":"R10-20260420","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1177\/11206721211005693","article-title":"Reper intraocular lens with artificial iris: Implantation techniques and outcomes","volume":"31","author":"Frisina","year":"2021","journal-title":"Eur J Ophthalmol"},{"key":"R11-20260420","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1159\/000511099","article-title":"Combined post-traumatic total aniridia and glaucoma management","volume":"12","author":"Christodoulou","year":"2021","journal-title":"Case Rep Ophthalmol"},{"key":"R12-20260420","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/ICB.0000000000000863","article-title":"Novel approach to scleral fixation of a Reper intraocular lens and artificial iris complex following pars plana lensectomy and vitrectomy for ectopia lentis and cataract in a patient with aniridia and nystagmus","volume":"15","author":"Jiang","year":"2021","journal-title":"Retin Cases Brief Rep"},{"key":"R13-20260420","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000528638","article-title":"A case of foldable artificial iris implantation for treatment of postcataract surgery aniridia","volume":"14","author":"Watanabe","year":"2023","journal-title":"Case Rep Ophthalmol"},{"key":"R14-20260420","doi-asserted-by":"crossref","first-page":"NP5","DOI":"10.1177\/1120672120902035","article-title":"A new intraocular lens with artificial iris for treating a case of iris extrusion secondary to traumatic opening of a radial keratotomy","volume":"31","author":"Frisina","year":"2021","journal-title":"Eur J Ophthalmol"},{"key":"R15-20260420","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1159\/000534277","article-title":"Two-step iridocorneal endothelial syndrome management: Endocapsular intraocular lens and artificial iris followed by Descemet\u2019s stripping automated endothelial keratoplasty","volume":"14","author":"Pinheiro-Costa","year":"2023","journal-title":"Case Rep Ophthalmol"},{"key":"R17-20260420","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1097\/j.jcrs.0000000000001147","article-title":"Artificial iris: State of the art","volume":"49","author":"Gius","year":"2023","journal-title":"J Cataract Refract 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Ophthalmol"},{"key":"R22-20260420","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1055\/a-1475-1049","article-title":"Use of the ophtec artificial iris model c1 in patients with Aniridia\/Aphakia","volume":"238","author":"Jakob-Girbig","year":"2021","journal-title":"Klin Monbl Augenheilkd"},{"key":"R23-20260420","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.ophtha.2022.01.029","article-title":"Results of the United States food and drug administration clinical trial of the customflex artificial iris","volume":"129","author":"Ayres","year":"2022","journal-title":"Ophthalmology"},{"key":"R24-20260420","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1097\/j.jcrs.0000000000000172","article-title":"Safety and efficacy of custom foldable silicone artificial iris implantation: Prospective compassionate-use case series","volume":"46","author":"Bonnet","year":"2020","journal-title":"J Cataract Refract Surg"}],"container-title":["Indian Journal of 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