{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:20:54Z","timestamp":1787761254472,"version":"build-2784847793"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Corneal collagen cross-linking (CXL) is a treatment strategy used in keratoconic eyes. Evaluation of long-term changes of higher-order aberrations (HOAs) after CXL is useful in understanding the efficacy of this procedure in improving optical, refractive, and visual acuity. This study aims to investigate the long-term effect of CXL on ocular HOA in patients with progressive keratoconus (KC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Using an OPD-Scan II aberrometer, ocular HOAs measurements of 56 eyes of 56 patients that underwent CXL was evaluated at the baseline, 1, 2, and 4 years after the procedure. All OPD-Scan measurements were decomposed into Zernike coefficients from 3\n                      <jats:sup>rd<\/jats:sup>\n                      to 6\n                      <jats:sup>th<\/jats:sup>\n                      order.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The results revealed that except for a few parameters, most of the aberration parameters continuously decreased during the study. In the 4-year postoperative period, a statistically significant improvement in all HOA parameters except 5\n                      <jats:sup>th<\/jats:sup>\n                      order Zernike polynomials (Z\n                      <jats:sub>5<\/jats:sub>\n                      <jats:sup>1<\/jats:sup>\n                      , Z\n                      <jats:sub>5<\/jats:sub>\n                      <jats:sup>\u22121<\/jats:sup>\n                      , Z\n                      <jats:sub>5<\/jats:sub>\n                      <jats:sup>3<\/jats:sup>\n                      , Z\n                      <jats:sub>5<\/jats:sub>\n                      <jats:sup>\u22123<\/jats:sup>\n                      , Z\n                      <jats:sub>5<\/jats:sub>\n                      <jats:sup>5<\/jats:sup>\n                      , and Z\n                      <jats:sub>5<\/jats:sub>\n                      <jats:sup>\u22125<\/jats:sup>\n                      ) was observed. All the values significantly decreased compared to the preoperative measurements (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). The mean \u00b1 standard deviation (SD) root mean square of the 3\n                      <jats:sup>rd<\/jats:sup>\n                      , 4\n                      <jats:sup>th<\/jats:sup>\n                      , and the 5\n                      <jats:sup>th<\/jats:sup>\n                      order as well as coma, coma like, and total HOA parameters were significantly decreased compared to both preoperative and previous visits (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). There were significant correlations between preoperative measurements of HOAs parameters with best-corrected visual acuity (BCVA) including Z\n                      <jats:sub>3<\/jats:sub>\n                      <jats:sup>1<\/jats:sup>\n                      , Z\n                      <jats:sub>3<\/jats:sub>\n                      <jats:sup>\u22121<\/jats:sup>\n                      , Z\n                      <jats:sub>4<\/jats:sub>\n                      <jats:sup>0<\/jats:sup>\n                      , Z\n                      <jats:sub>5<\/jats:sub>\n                      <jats:sup>1<\/jats:sup>\n                      , and Z\n                      <jats:sub>4<\/jats:sub>\n                      <jats:sup>2<\/jats:sup>\n                      . Moreover, all the HOAs parameters in 4 years after the CXL were significantly correlated with BCVA (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>CXL is effective in improving HOA parameters in eyes with progressive KC during a long-term follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_21_17","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T23:17:01Z","timestamp":1505776621000},"page":"808-812","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Higher-order aberration 4 years after corneal collagen 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