{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:33:51Z","timestamp":1786739631479,"version":"build-2736575974"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To describe a new technique of intracorneal scleral patch (ICSP) supported cyanoacrylate tissue adhesive (CTA) application in corneal perforations, greater than 3.0 mm secondary to rheumatoid arthritis (RA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This Prospective, non-randomized, non-comparative, interventional series included 14 eyes (14 patients). All patients had corneal perforations sized 3.5 to 4.5 mm due to RA, which were treated with ICSP supported CTA application. A partial thickness scleral patch 1.0 mm larger than diameter of corneal perforation was prepared. A lamellar corneal pocket 0.5 mm all around the corneal perforation was created. The partial thickness scleral patch was placed in the corneal perforation site and the edge was fitted into the lamellar intracorneal pocket. A minimum quantity of CTA was applied on the scleral patch to seal the perforation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The corneal perforations healed in 14 eyes (100%) in a mean 7.71 \u00b1 1.14 (range, 6\u20139) weeks. One eye (7.14%) had inadvertent extrusion of ICSP due to premature removal of CTA but, Seidel's test was negative, and the corneal epithelial defect healed with BCL alone. One eye each (7.14%) developed steroid induced cataract and glaucoma. None of eyes developed infective keratitis, re-opening of corneal perforation (necessitating repeat procedure) or enlargement of corneal perforation requiring penetrating keratoplasty (PKP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>ICSP supported CTA application is a successful alternative option to emergency PKP in treating corneal perforations sized 3.5 to 4.5 mm with associated RA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2258_19","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T08:27:00Z","timestamp":1608020820000},"page":"69-73","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["Intracorneal scleral patch supported cyanoacrylate application for corneal perforations secondary to rheumatoid arthritis"],"prefix":"10.4103","volume":"69","author":[{"given":"Ashok","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajan","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verinder S","family":"Nirankari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-18-20240828","first-page":"399","article-title":"Chronic corneal perforations","volume":"23","author":"Saini","year":"1992","journal-title":"Ophthalmic Surg"},{"key":"R2-18-20240828","first-page":"92","article-title":"Management of corneal descemetoceles and perforations","volume":"82","author":"Arentsen","year":"1984","journal-title":"Trans Am Ophthalmol Soc"},{"key":"R3-18-20240828","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.ajo.2005.04.062","article-title":"The effectiveness of isobutyl cyanoacrylate tissue adhesive for the treatment of corneal perforations","volume":"140","author":"Setlik","year":"2005","journal-title":"Am J Ophthalmol"},{"key":"R4-18-20240828","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0161-6420(02)01558-0","article-title":"Fibrin glue versus N-butyl-2-cyanoacrylate in corneal perforations","volume":"110","author":"Sharma","year":"2003","journal-title":"Ophthalmology"},{"key":"R5-18-20240828","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.survophthal.2011.06.003","article-title":"Management of corneal perforation","volume":"56","author":"Jhanji","year":"2011","journal-title":"Surv Ophthalmol"},{"key":"R6-18-20240828","first-page":"256","article-title":"Corneal endothelial polymerization of histoacryl adhesive: A report of a new intraocular complication","volume":"26","author":"Markowitz","year":"1995","journal-title":"Ophthalmic Surg"},{"key":"R7-18-20240828","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1097\/ICO.0b013e31818200d2","article-title":"Therapeutic keratoplasty for corneal perforation","volume":"27","author":"Hanada","year":"2008","journal-title":"Cornea"},{"key":"R8-18-20240828","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0002-9394(02)02172-4","article-title":"Therapeutic deep lamellar keratoplasty for cornea perforation","volume":"135","author":"Shimmura","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"R9-18-20240828","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1001\/archopht.1990.01070090041035","article-title":"Results of penetrating keratoplasty for the treatment of corneal perforations","volume":"108","author":"Nobe","year":"1990","journal-title":"Arch Ophthalmol"},{"key":"R10-18-20240828","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1097\/ICO.0b013e318191b857","article-title":"Penetrating keratoplasty with small-diameter and glycerin-cryopreserved grafts for eccentric corneal perforations","volume":"28","author":"Shi","year":"2009","journal-title":"Cornea"},{"key":"R11-18-20240828","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000063847","article-title":"Outcome of penetrating keratoplasty in rheumatoid arthritis","volume":"216","author":"Pleyer","year":"2002","journal-title":"Ophthalmologica"},{"key":"R12-18-20240828","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/S0161-6420(95)30867-6","article-title":"The management of corneal perforations associated with rheumatoid arthritis. 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