{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:35:14Z","timestamp":1786649714152,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,6]]},"abstract":"\n Purpose:<\/jats:title>\n \n To compare the visual outcomes following topography-guided laser\n in situ<\/jats:italic>\n keratomileusis (LASIK) treatment using manifest refraction versus a new topography analysis software.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A prospective, randomized, observer-masked contralateral study was conducted in the refractive services of a tertiary eye care hospital in South India. Analysis of visual outcomes, corneal higher-order aberrations, and contrast sensitivity were performed at 3 months postoperative visit following uneventful topography-guided LASIK using the Wavelight EX500. One eye was treated with the Contoura platform using manifest refraction (Contoura), while the contralateral eye was treated using an ablation profile planned by the Phorcides Analytic Engine (Phorcides).<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Sixty eyes of 30 patients were included in the study. At 3 months postoperative visit, the uncorrected distance visual acuity (UDVA) in the Contoura and Phorcides groups was logarithm of the minimal angle of resolution (logMAR) 0.04 \u00b1 0.07 and logMAR 0.06 \u00b1 0.1, respectively (\n P<\/jats:italic>\n = 0.483). Postoperative manifest refractive spherical error (MRSE) was 0.12 \u00b1 0.22 and \u2212 0.06 \u00b1 0.20 D in the Contoura and Phorcides groups, respectively (\n P<\/jats:italic>\n = 0.338). Although higher number of eyes demonstrated a gain in one or more lines of corrected distance visual acuity (CDVA) in the Contoura group (16.6% vs. 6.6%), the difference was not statistically significant (\n P<\/jats:italic>\n = 0.361). Vector analysis (Alpins criteria) for postoperative cylinder, contrast sensitivity measurement, and corneal higher-order aberration profile showed no significant difference between the two groups at 3 months postoperative visit (\n P<\/jats:italic>\n = 0.213, 0.514, and 0.332, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Quantitative and qualitative visual outcomes with the Phorcides Analytic Software were similar to the Contoura treatment using manifest refraction.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijo.ijo_226_23","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T09:06:03Z","timestamp":1686733563000},"page":"2430-2435","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Comparative analysis of outcomes following topography-guided laser in situ keratomileusis using manifest refraction versus a new topographic analysis algorithm"],"prefix":"10.4103","volume":"71","author":[{"given":"Gitansha S","family":"Sachdev","sequence":"first","affiliation":[{"name":"Cornea and Refractive Services, The Eye Foundation, Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreyas","family":"Ramamurthy","sequence":"additional","affiliation":[{"name":"Cornea and Refractive Services, The Eye Foundation, Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Soundarya","sequence":"additional","affiliation":[{"name":"Cornea and Refractive Services, The Eye Foundation, Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramamurthy","family":"Dandapani","sequence":"additional","affiliation":[{"name":"Cornea and Refractive Services, The Eye Foundation, Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,6,14]]},"reference":[{"key":"R1-20251006","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jcrs.2015.08.016","article-title":"Results of topography-guided laser in situ keratomileusis custom ablation treatment with a refractive excimer laser","volume":"42","author":"Stulting","year":"2016","journal-title":"J Cataract Refract Surg"},{"key":"R2-20251006","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.2147\/OPTH.S122345","article-title":"Topography-modified refraction (TMR):Adjustment of treated cylinder amount and axis to the topography versus standard clinical refraction in myopic topography-guided LASIK","volume":"10","author":"Kanellopoulos","year":"2016","journal-title":"Clin Ophthalmol"},{"key":"R3-20251006","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3928\/1081597X-20181113-01","article-title":"Primary topography-guided LASIK:Treating manifest refractive astigmatism versus topography-measured anterior corneal astigmatism","volume":"35","author":"Wallerstein","year":"2019","journal-title":"J Refract Surg"},{"key":"R4-20251006","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3928\/1081597X-20190304-02","article-title":"Comparison of wavefront-optimized ablation and topography-guided Contoura ablation with LYRA protocol in LASIK","volume":"35","author":"Ozulken","year":"2019","journal-title":"J Refract Surg"},{"key":"R5-20251006","first-page":"814","article-title":"Clinical outcomes after topography-guided LASIK:Comparing results based on a new topography analysis algorithm with those based on manifest refraction J Cataract Refract Surg","volume":"46","author":"Lobanoff","year":"2020"},{"key":"R6-20251006","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.4103\/ijo.IJO_507_18","article-title":"Comparative analysis of visual outcomes and ocular aberrations following wavefront optimized and topography-guided customized femtosecond laser in situ keratomileusis for myopia and myopic astigmatism:A contralateral eye study","volume":"66","author":"Tiwari","year":"2018","journal-title":"Indian J Ophthalmol"},{"key":"R7-20251006","doi-asserted-by":"crossref","first-page":"575","DOI":"10.3928\/1081597X-20190819-01","article-title":"A randomized comparative study of topography-guided versus wavefront-optimized FS-LASIK for correcting myopia and myopic astigmatism","volume":"35","author":"Zhang","year":"2019","journal-title":"J Refract Surg"},{"key":"R8-20251006","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.2147\/OPTH.S280959","article-title":"Clinical outcomes after topography-guided refractive surgery in eyes with myopia and astigmatism-Comparing results with new planning software to those obtained using the manifest refraction","volume":"14","author":"Brunson","year":"2020","journal-title":"Clin Ophthalmol"},{"key":"R9-20251006","first-page":"240","article-title":"Topographically guided LASIK for myopia using the Nidek CXII customized aspheric treatment zone (CATz)","volume":"105","author":"Waring","year":"2007","journal-title":"Trans Am Ophthalmol Soc"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_226_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:57:30Z","timestamp":1786647450000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_226_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_226_23","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"2023-01-24","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-21","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}