{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:21:47Z","timestamp":1787775707907,"version":"build-2784847793"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>Forty-eight pediatric patients treated for endogenous endophthalmitis were analyzed. Redness and vitritis were the common symptom and sign, respectively; infection with Gram-negative bacilli was frequent. Children under 5 and with systemic illness had poorer visual prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To Analyze the demographics, clinical-microbiological profiles, and treatment outcomes of pediatric patients with endogenous endophthalmitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis of electronic medical records covering 8 years from 2016 to 2023 at a tertiary eye care center in India, focusing on patients of age &lt;18 years diagnosed with endogenous endophthalmitis. Data extraction included demographic variables, clinical presentations, microbiological analyses, therapeutic interventions, and visual outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The analysis included 48 patients with an average age of 5.4 \u00b1 4.98 years and an equal gender ratio. During the study period, 48 children with endogenous endophthalmitis were treated; it was 5% (48 of 961) of all endophthalmitis patients and 20.8% (48 of 231) of pediatric endophthalmitis patients. Common symptoms included redness (62.5%), reduced vision (20.8%), leucocoria (27.08%), pain (22.91%), and watering\/discharge (29.16%). Clinical signs included vitritis (89.58%) and anterior chamber exudates\/hypopyon (47.91%). Vitreous culture positivity was 54.05%; common isolates were Gram-negative bacilli (35%), Gram-positive cocci (25%), and Gram-positive bacilli and fungi (20% each). Systemic infection was present in 72.9% (35 of 48) of patients, with respiratory tract infection being the most common (39.5%). All eyes received intravitreal antibiotic injections, and 28 (75.7%) received vitrectomy. Children under 5 with systemic illness had a worse visual prognosis. Unfavorable outcomes were associated with Gram-positive bacilli and fungal infection. Approximately 45% of eyes worsened to phthisis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Any redness in a child with systemic infection warrants prompt ophthalmic evaluation. Children under 5 with systemic illness are associated with a worse visual prognosis. Unfavorable outcomes are linked to Gram-positive bacilli and fungal infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2298_24","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T11:00:24Z","timestamp":1745492424000},"page":"665-671","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Pediatric endogenous endophthalmitis: Clinical features and treatment outcomes"],"prefix":"10.4103","volume":"73","author":[{"given":"Ridham","family":"Nanda","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, LV Prasad Eye Institute, Mithu Tulasi Chanrai Campus, Anant Bajaj Retina Institute, Bhubaneswar, Odisha, India"},{"name":"Department of Ophthalmology, AIIMS Vijaypur, Jammu, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taraprasad","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, LV Prasad Eye Institute, Kalam Anji Reddy Campus, Anant Bajaj Retina Institute, Srimati Kanuri Santhmma Centre for Vitreoretinal Diseases, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapas Ranjan","family":"Padhi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, LV Prasad Eye Institute, Mithu Tulasi Chanrai Campus, Anant Bajaj Retina Institute, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krushna Gopal","family":"Panda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, LV Prasad Eye Institute, Mithu Tulasi Chanrai Campus, Anant Bajaj Retina Institute, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Ger","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, LV Prasad Eye Institute, Mithu Tulasi Chanrai Campus, Anant Bajaj Retina Institute, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srikanta Kumar","family":"Padhy","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, LV Prasad Eye Institute, Mithu Tulasi Chanrai Campus, Anant Bajaj Retina Institute, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,4,24]]},"reference":[{"key":"R1-20260422","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/infdis\/162.1.115","article-title":"The clinical spectrum of endophthalmitis: incidence, predisposing factors, and features influencing outcome","volume":"162","author":"Shrader","year":"1990","journal-title":"J 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