{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:32:25Z","timestamp":1787758345404,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10]]},"abstract":"\n Purpose:<\/jats:title>\n To evaluate and correlate corneal endothelium parameters with the severity of primary glaucoma.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n This prospective case-control study was conducted on 150 eyes of 80 newly diagnosed primary open-angle glaucoma (POAG), chronic primary angle-closure glaucoma (cPACG), and normal-tension glaucoma (NTG) patients in a tertiary care center. Endothelial parameters including endothelial cell count (ECC), percentage of hexagonal cells, and coefficient of variation of cell size were analyzed. Glaucoma cases were further sub-grouped into early, moderate, and severe glaucoma and compared for endothelial parameters. Chi-square, Fischer\u2019s exact test, independent sample\n t<\/jats:italic>\n -test, and analysis of variance were performed using IBM\n \u00ae<\/jats:sup>\n SPSS\n \u00ae<\/jats:sup>\n Statistics version 28.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The ECC was markedly reduced in cases (2281 cells\/mm\n 2<\/jats:sup>\n ) versus controls (2611 cells\/mm\n 2<\/jats:sup>\n ) (\n P<\/jats:italic>\n < 0.001). The POAG (2251 cells\/mm\n 2<\/jats:sup>\n ) and cPACG (2287 cells\/mm\n 2<\/jats:sup>\n ) eyes had significantly a lower ECC compared to healthy controls (\n P<\/jats:italic>\n < 0.001), whereas NTG eyes had a lower mean ECC (2538 cells\/mm\n 2<\/jats:sup>\n ), but it was not statistically significant (\n P<\/jats:italic>\n > 0.05) when compared with controls. The ECC decreased with an increase in severity as patients with early glaucoma had an ECC of 2284 cells\/mm\n 2<\/jats:sup>\n , moderate 2261 cells\/mm\n 2<\/jats:sup>\n , and severe 2086 cells\/mm\n 2<\/jats:sup>\n , and the difference was statistically significant.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n A significant decrease in corneal ECC was observed in POAG and cPACG patients when compared with healthy controls of the same age group. Mechanical damage following an elevated intra-ocular pressure for a longer duration may be attributed to morphological and consequent functional damage to endothelial cells.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijo.ijo_234_22","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T11:10:13Z","timestamp":1665054613000},"page":"3540-3543","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation and correlation of corneal endothelium parameters with the severity of primary glaucoma"],"prefix":"10.4103","volume":"70","author":[{"given":"Diksha","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Regional Institute of Ophthalmology, GMC, Amritsar, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prempal","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Regional Institute of Ophthalmology, GMC, Amritsar, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karamjit","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Regional Institute of Ophthalmology, GMC, Amritsar, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Regional Institute of Ophthalmology, GMC, Amritsar, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riya","family":"Chopra","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Regional Institute of Ophthalmology, GMC, Amritsar, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurang","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Regional Institute of Ophthalmology, GMC, Amritsar, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"key":"B1-20240828","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1167\/iovs.05-1139","article-title":"The balance between corneal transparency and edema the proctor lecture","volume":"47","author":"Edelhauser","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B2-20240828","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/S0161-6420(82)34744-2","article-title":"Corneal endothelial changes in primary acute angle-closure glaucoma","volume":"89","author":"Bigar","year":"1982","journal-title":"Ophthalmology"},{"key":"B3-20240828","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1111\/j.1755-3768.1979.tb00531.x","article-title":"Corneal endothelial cell density after an attack of acute glaucoma","volume":"57","author":"Set\u00e4l\u00e4","year":"1979","journal-title":"Acta Ophthalmologica"},{"key":"B4-20240828","first-page":"786","article-title":"Morphometric and qualitative changes in corneal endothelium in pseudoexfoliation syndrome","volume":"88","author":"Knorr","year":"1991","journal-title":"Fortschr Ophthalmol"},{"key":"B5-20240828","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.12998\/wjcc.v7.i15.1978","article-title":"Changes in corneal endothelial cell density in patients with primary open-angle glaucoma","volume":"7","author":"Yu","year":"2019","journal-title":"World J Clin Cases"},{"key":"B6-20240828","doi-asserted-by":"crossref","first-page":"e76434","DOI":"10.1371\/journal.pone.0076434","article-title":"Prevalence and associated factors of glaucoma in rural central India. 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