{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:34:44Z","timestamp":1786649684961,"version":"build-2736575974"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate differences in the iris and angle parameters in psuedoexfoliation syndrome (PXF) and pseudoexfoliation glaucoma (PXG) using anterior segment optical coherence tomography (ASOCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients with PXF or PXG were compared using ASOCT with primary open-angle glaucoma POAG eyes as controls in this noninterventional comparative study conducted at a tertiary eye care center in East India. All angle parameters, TM length, and iris thickness were analyzed from the enhanced depth imaging (EDI) single scans obtained. Quadrant scans were used for the calculation of iris volume using a custom-built in-house software. In particular, the software performs multiple operations including edge detection, connected components, and thresholding to localize and segment the iris. Differences in the iris volume\/thickness and TM length in PXF and PXG with POAG were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 225 eyes were included, which included 75 PXG and 98 PXF cases and 52 POAG with a mean age of 67 \u00b1 9.7 years at presentation. The algorithm repeatability and reproducibility was also established with correlation coefficients more than 99% which was substantiated with Bland-Altman plots. The iris volume (calculated in 197 images of 225 eyes) did not differ significantly in PXF and PXG eyes, although both had significantly greater volume compared to POAG eyes. The iris volume or other angle parameters including TM length did not correlate with clinical variables such as IOP, age, or visual field indices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Iris parameters or TM length do not explain pathogenesis of glaucoma in pseudoexfoliation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2403_20","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T14:43:02Z","timestamp":1624632182000},"page":"1815-1819","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Automated iris volume analysis and trabecular meshwork length using anterior segment optical coherence tomography - Application in pseudoexfoliation and pseudoexfoliation glaucoma"],"prefix":"10.4103","volume":"69","author":[{"given":"Aparna","family":"Rao","sequence":"first","affiliation":[{"name":"LV Prasad Eye Institute, Patia, Bhubaneswar, Orissa, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran Kumar","family":"Vupparaboina","sequence":"additional","affiliation":[{"name":"LV Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debananda","family":"Padhy","sequence":"additional","affiliation":[{"name":"LV Prasad Eye Institute, Patia, Bhubaneswar, Orissa, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niranjan","family":"Raj","sequence":"additional","affiliation":[{"name":"LV Prasad Eye Institute, Patia, Bhubaneswar, Orissa, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amiya","family":"Pradhan","sequence":"additional","affiliation":[{"name":"LV Prasad Eye Institute, Patia, Bhubaneswar, Orissa, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abilash","family":"Goud","sequence":"additional","affiliation":[{"name":"LV Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari Kumar","family":"Peguda","sequence":"additional","affiliation":[{"name":"LV Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumya","family":"Jana","sequence":"additional","affiliation":[{"name":"LV Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Richariya","sequence":"additional","affiliation":[{"name":"LV Prasad Eye Institute, Patia, Bhubaneswar, Orissa, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,6,18]]},"reference":[{"key":"R1-20260523","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/APO.0000000000000179","article-title":"Optical coherence tomography imaging for glaucoma-today and tomorrow","volume":"5","author":"Leung","year":"2016","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"key":"R2-20260523","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/ICU.0000000000000243","article-title":"New developments in anterior segment optical coherence tomography for glaucoma","volume":"27","author":"Wang","year":"2016","journal-title":"Curr Opin Ophthalmol"},{"key":"R3-20260523","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cmpb.2016.03.018","article-title":"Automated anterior segment OCT image analysis for Angle Closure Glaucoma mechanisms classification","volume":"130","author":"Niwas","year":"2016","journal-title":"Comput Methods Programs Biomed"},{"key":"R4-20260523","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/ICU.0000000000000026","article-title":"Development in anterior segment imaging for glaucoma","volume":"25","author":"Radhakrishnan","year":"2014","journal-title":"Curr Opin Ophthalmol"},{"key":"R5-20260523","doi-asserted-by":"crossref","first-page":"5320","DOI":"10.1167\/iovs.16-20006","article-title":"Biometric factors associated with acute primary angle closure:Comparison of the affected and fellow eye","volume":"57","author":"Atalay","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R6-20260523","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1167\/iovs.12-10844","article-title":"Variations in iris volume with physiologic mydriasis in subtypes of primary angle closure glaucoma","volume":"54","author":"Narayanaswamy","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R7-20260523","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1167\/iovs.11-9387","article-title":"Biometric evaluation of anterior chamber changes after physiologic pupil dilation using Pentacam and anterior segment optical coherence tomography","volume":"53","author":"Aptel","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R8-20260523","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0161-6420(98)96020-1","article-title":"Pseudoexfoliation syndrome for the comprehensive ophthalmologist. Intraocular and systemic manifestations","volume":"105","author":"Naumann","year":"1998","journal-title":"Ophthalmology"},{"key":"R9-20260523","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/BF00462029","article-title":"Pseudoexfoliation syndrome with poorly dilating pupil:A light and electron microscopic study of the sphincter area","volume":"234","author":"Repo","year":"1996","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"R10-20260523","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/S0161-6420(95)30873-1","article-title":"A histopathologic study of iris changes in pseudoexfoliation syndrome","volume":"102","author":"Asano","year":"1995","journal-title":"Ophthalmology"},{"key":"R11-20260523","doi-asserted-by":"crossref","first-page":"e113329","DOI":"10.1371\/journal.pone.0113329","article-title":"Pattern of pseudoexfoliation deposits on the lens and their clinical correlation- clinical study and review of literature","volume":"9","author":"Rao","year":"2014","journal-title":"PLoS One"},{"key":"R12-20260523","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ajo.2015.11.007","article-title":"Association between trabecular meshwork anteroposterior length and anterior chamber angle width","volume":"162","author":"Lee","year":"2016","journal-title":"Am J Ophthalmol"},{"key":"R13-20260523","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1001\/archopht.119.7.1023","article-title":"Unilateral or asymmetric pseudoexfoliation syndrome?An ultrastructural study","volume":"119","author":"Hammer","year":"2001","journal-title":"Arch Ophthalmol"},{"key":"R14-20260523","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1016\/S0161-6420(91)32102-X","article-title":"Iris in pseudoexfoliation","volume":"98","author":"Foos","year":"1991","journal-title":"Ophthalmology"},{"key":"R15-20260523","first-page":"7","article-title":"Fluorescein angiography and indocyanine green video angiography in the iris of pseudoexfoliation syndrome","volume":"21","author":"Battaglia Parodi","year":"1998","journal-title":"Metab Pediatr Syst Ophthalmol"},{"key":"R16-20260523","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/sj.eye.6702602","article-title":"The spectrum of iris angiography abnormalities in pseudoexfoliation syndrome","volume":"22","author":"Parodi","year":"2008","journal-title":"Eye (Lond)"},{"key":"R17-20260523","first-page":"148","article-title":"Anterior-chamber hypoxia and iris vasculopathy in pseudoexfoliation syndrome","volume":"3","author":"Helbig","year":"1994","journal-title":"Ger J Ophthalmol"},{"key":"R18-20260523","first-page":"754","article-title":"Ultrasound biomicroscopy in patients with unilateral pseudoexfoliation","volume":"18","author":"\u00dcnsal","year":"2015","journal-title":"Int J Ophthalmol"},{"key":"R19-20260523","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.1444-0938.2011.00691.x","article-title":"Evaluation of Pentacam-Scheimpflug imaging of anterior segment parameters in patients with pseudoexfoliation syndrome and pseudoexfoliative glaucoma","volume":"95","author":"Doganay","year":"2012","journal-title":"Clin Exp Optom"},{"key":"R20-20260523","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ophtha.2009.10.030","article-title":"Optical coherence tomography quantitative analysis of iris volume changes after pharmacologic mydriasis","volume":"117","author":"Aptel","year":"2010","journal-title":"Ophthalmology"},{"key":"R21-20260523","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1016\/j.ophtha.2013.05.009","article-title":"Imaging the iris with swept-source optical coherence tomography:Relationship between iris volume and primary angle closure","volume":"120","author":"Mak","year":"2013","journal-title":"Ophthalmology"},{"key":"R22-20260523","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000448523","article-title":"Evaluation of the narrow anterior chamber angle by anterior segment optical coherence tomography","volume":"57","author":"Lan","year":"2017","journal-title":"Ophthalmic Res"},{"key":"R23-20260523","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.joco.2016.09.006","article-title":"Anterior segment optical coherence tomography in subtypes of angle closure glaucoma","volume":"28","author":"Nouri-Mahdavi","year":"2016","journal-title":"J Curr Ophthalmol"},{"key":"R24-20260523","doi-asserted-by":"crossref","first-page":"630","DOI":"10.4103\/0301-4738.169787","article-title":"Anterior segment imaging in glaucoma:An updated review","volume":"63","author":"Maslin","year":"2015","journal-title":"Indian J Ophthalmol"},{"key":"R25-20260523","first-page":"1","article-title":"Comparison of anterior segment optical coherence tomography and ultrasound biomicroscopy for iris parameter measurements in patients with primary angle closure glaucoma","volume":"28","author":"Wang","year":"2013","journal-title":"Eye Sci"},{"key":"R26-20260523","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/sj.eye.6703050","article-title":"Morphological changes of the anterior segment after laser peripheral iridotomy in primary angle closure","volume":"23","author":"Lei","year":"2009","journal-title":"Eye (Lond)"},{"key":"R27-20260523","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1167\/iovs.14-16154","article-title":"Morphometry of the trabecular meshwork in vivo in a healthy population using fourier-domain optical coherence tomography","volume":"56","author":"Fern\u00e1ndez-Vigo","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R28-20260523","doi-asserted-by":"crossref","first-page":"6934","DOI":"10.1167\/iovs.10-7009","article-title":"Identification of Schlemm's canal and its surrounding tissues by anterior segment fourier domain optical coherence tomography","volume":"52","author":"Usui","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R29-20260523","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1109\/TSMC.1979.4310076","article-title":"A threshold selection method from Gray-Level Histograms","volume":"9","author":"Otsu","year":"1979","journal-title":"IEEE Trans Syst Man Cyber"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijo.IJO_2403_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:57:01Z","timestamp":1786647421000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijo.IJO_2403_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,18]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_2403_20","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,18]]},"assertion":[{"value":"2020-09-06","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-02","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}