{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:22:51Z","timestamp":1787844171823,"version":"build-2784847793"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To study topical timolol (0.5%) as a first-line treatment in ophthalmic pyogenic granuloma (PG) in terms of safety and efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a prospective, interventional, single-arm study conducted at a tertiary eye care hospital in central India. Only new cases of PG were counseled to get enrolled in the study. A total of 40 patients were analyzed in the study. Topical timolol eye drop (0.5%) was started in each patient twice daily for 4\u20136 weeks duration. The patients were divided into five categories according to the percentage reduction in the size of PG as follows: i) 80\u2013100% reduction - excellent responders, ii) 60\u201380% \u2013 good, iii) 40\u201360% \u2013 satisfactory, iv) 20\u201340% \u2013 poor, and v) &lt;20% \u2013 very poor\/nonresponder. After 6 months of starting treatment final evaluation was done.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean age of the patients was 23.5 \u00b1 13.3 years. Etiology of the disease included chalazion (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 11, 27.5%), trauma (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 2, 5%), surgery (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 7, 17.5%), foreign body (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 2, 5%), and idiopathic (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 18, 45%). An excellent response was achieved in 31 (77.5%) patients. Twenty-seven (67.5%) patients had complete resolution of lesions within 6 weeks. Recurrence of the lesion was not noticed in any patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Timolol 0.5% in topical form is a good treatment option for ophthalmic PG in all age groups. The treatment has no adverse effects when given to suitable individuals for a limited period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2404_20","type":"journal-article","created":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T11:32:28Z","timestamp":1619955148000},"page":"1155-1160","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Topical timolol 0.5% as the primary treatment of ophthalmic pyogenic granuloma: A prospective, single-arm study"],"prefix":"10.4103","volume":"69","author":[{"given":"Hrishabh","family":"Jaiswal","sequence":"first","affiliation":[{"name":"Department of Orbit and Oculoplasty, Sadguru Netra Chikitsalya and Postgraduate Institute of Ophthalmology, Jankikund, Chitrakoot, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narendra","family":"Patidar","sequence":"additional","affiliation":[{"name":"Department of Orbit and Oculoplasty, Sadguru Netra Chikitsalya and Postgraduate Institute of Ophthalmology, Jankikund, Chitrakoot, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chintan","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pediatric Ophthalmology and Strabismus, Sadguru Netra Chikitsalya and Postgraduate Institute of Ophthalmology, Jankikund, Chitrakoot, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rukmendra","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elesh","family":"Jain","sequence":"additional","affiliation":[{"name":"Consultant and Administrator, Sadguru Netra Chikitsalya and Postgraduate Institute of Ophthalmology, Jankikund, Chitrakoot, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parimal","family":"Piyush","sequence":"additional","affiliation":[{"name":"Department of Orbit and Oculoplasty, Sadguru Netra Chikitsalya and Postgraduate Institute of Ophthalmology, Jankikund, Chitrakoot, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,4,30]]},"reference":[{"key":"B1-20240828","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1001\/jamaophthalmol.2017.0110","article-title":"Treatment of ocular pyogenic granuloma with topical timolol","volume":"135","author":"Oke","year":"2017","journal-title":"JAMA Ophthalmol"},{"key":"B2-20240828","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3889\/oamjms.2017.111","article-title":"Pyogenic granuloma - 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