{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:52:58Z","timestamp":1791211978991,"version":"4.1.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 3","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,10]]},"abstract":"\n Purpose:<\/jats:title>\n This study aimed to evaluate changes in lenticular structures using the Pentacam HR in patients with acromegaly.<\/jats:p>\n <\/jats:sec>\n \n Design:<\/jats:title>\n Prospective observational study.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A total of 40 patients with acromegaly and 40 healthy volunteers were included in this prospective observational study. For anterior segment evaluation, lens densitometry values were analyzed in designated regions using the Pentacam HR Scheimpflug imaging system. The average values were calculated from predefined three-dimensional zones (Zone 1: 2.0 mm, Zone 2: 4.0 mm, and Zone 3: 6.0 mm), with the center of the pupil as the reference point.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Lens densitometry values in Zone 1, Zone 2, and Zone 3 were significantly higher in the acromegaly group compared to the control group (\n P<\/jats:italic>\n < 0.05 for each). Both maximum and mean lens densitometry values were also significantly elevated in the acromegaly group (\n P<\/jats:italic>\n = 0.046 and\n P<\/jats:italic>\n = 0.041, respectively). A moderate but significant positive correlation was found between growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels and the lens densitometry values in all three zones (\n P<\/jats:italic>\n < 0.05 for each).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Lens densitometry was significantly higher in acromegaly patients than in healthy controls, and these values were positively correlated with IGF-1 and GH levels.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2445_25","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:00:34Z","timestamp":1790953234000},"page":"S417-S422","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Lens densitometry alterations in acromegaly: Quantitative insights from Scheimpflug imaging and hormonal correlation"],"prefix":"10.4103","volume":"74","author":[{"given":"Mehmet Egemen","family":"Karata\u015f","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, \u015ei\u015fli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamze","family":"Karata\u015f","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Prof.Dr.Cemil Ta\u015fc\u0131o\u011flu City Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sezin Do\u011fan","family":"\u00c7ak\u0131r","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Prof.Dr.Cemil Ta\u015fc\u0131o\u011flu City Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"R1-20261005","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1210\/er.2002-0022","article-title":"Systemic complications of acromegaly: Epidemiology, pathogenesis, and management","volume":"25","author":"Colao","year":"2004","journal-title":"Endocr Rev"},{"key":"R2-20261005","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s11102-006-0409-4","article-title":"Acromegaly","volume":"9","author":"Scacchi","year":"2006","journal-title":"Pituitary"},{"key":"R3-20261005","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1136\/bjophthalmol-2013-304277","article-title":"Corneal biomechanical properties of patients with acromegaly","volume":"98","author":"Ozkok","year":"2014","journal-title":"Br J Ophthalmol"},{"key":"R4-20261005","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3109\/02713683.2014.967872","article-title":"Tear osmolarity and tear function changes in patients with acromegaly","volume":"40","author":"Arici","year":"2015","journal-title":"Curr Eye Res"},{"key":"R5-20261005","doi-asserted-by":"crossref","first-page":"101397","DOI":"10.1016\/j.ghir.2021.101397","article-title":"Lacrimal gland enlargement and tear film changes in acromegaly patients: A controlled study","volume":"59","author":"Mergen","year":"2021","journal-title":"Growth Horm IGF Res"},{"key":"R6-20261005","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/eye.2014.216","article-title":"Chorio-retinal thickness measurements in patients with acromegaly","volume":"28","author":"Pekel","year":"2014","journal-title":"Eye (Lond)"},{"key":"R7-20261005","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ghir.2014.08.003","article-title":"Corneal endothelial cell density and morphology in patients with acromegaly","volume":"24","author":"Hatipoglu","year":"2014","journal-title":"Growth Horm IGF Res"},{"key":"R8-20261005","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/ICO.0000000000000297","article-title":"Topographic and biomechanical evaluation of cornea in patients with acromegaly","volume":"34","author":"Altinkaynak","year":"2015","journal-title":"Cornea"},{"key":"R9-20261005","doi-asserted-by":"crossref","first-page":"101424","DOI":"10.1016\/j.ghir.2021.101424","article-title":"Changes in anterior segment parameters and presence of dry eye disease in patients with acromegaly: A sirius topography study combined with meibography","volume":"60-61","author":"Kilic","year":"2021","journal-title":"Growth Horm IGF Res"},{"key":"R10-20261005","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000055519","article-title":"An index for human lens transparency related to age and lens layer: Comparison between normal volunteers and diabetic patients with still clear lenses","volume":"31","author":"Sasaki","year":"1999","journal-title":"Ophthalmic Res"},{"key":"R11-20261005","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1136\/bjophthalmol-2019-314171","article-title":"Correlation between lens thickness and lens density in patients with mild to moderate cataracts","volume":"104","author":"Henriquez","year":"2020","journal-title":"Br J Ophthalmol"},{"key":"R12-20261005","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/BF03347058","article-title":"Cornea in acromegalic patients as a possible target of growth hormone action","volume":"34","author":"Ciresi","year":"2011","journal-title":"J Endocrinol Invest"},{"key":"R13-20261005","doi-asserted-by":"crossref","first-page":"841","DOI":"10.4103\/0301-4738.141035","article-title":"Comparing acromegalic patients to healthy controls with respect to intraocular pressure, central corneal thickness, and optic disc topography findings","volume":"62","author":"Sen","year":"2014","journal-title":"Indian J Ophthalmol"},{"key":"R14-20261005","first-page":"27","article-title":"Elevated IGF-1 and GH levels are correlated with a thicker iris and wider anterior chamber angle in treatment-na\u00efve acromegaly patients","volume":"63","author":"Zhang","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R15-20261005","first-page":"179","article-title":"Expression of the insulin-like growth factor 1 (IGF-1) and type I IGF receptor mRNAs in human HLE-B3 lens epithelial cells","volume":"25","author":"Moschos","year":"2011","journal-title":"In Vivo"},{"key":"R16-20261005","doi-asserted-by":"crossref","first-page":"103773","DOI":"10.1016\/j.pdpdt.2023.103773","article-title":"Corneal parameters, ocular biometers, and retinal and choroidal thickness in acromegaly patients","volume":"44","author":"Batur","year":"2023","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"R17-20261005","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1006\/exer.2000.0846","article-title":"Insulin and IGF-I affect the protein composition of the lens fibre cell with possible consequences for cataract","volume":"70","author":"Civil","year":"2000","journal-title":"Exp Eye 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3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_2445_25","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2025-09-26","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-12","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}