{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:36:31Z","timestamp":1786649791675,"version":"build-2736575974"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>The second wave of coronavirus disease 2019 (COVID-19) pandemic triggered a mucormycosis epidemic in India. Diabetes mellitus and dysregulated immune response were contributors, and rhino-orbital-cerebral mucormycosis (ROCM) was the most common presentation. It is however not known whether bio-chemical parameters at presentation correlate with stage of ROCM or final outcome in terms of vision or mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective, hospital-based study included all in-patients of mucormycosis with ophthalmic manifestations at presentation admitted during June 1, 2021 to August 31, 2021. It aimed to evaluate the association between severity of infection, serum levels of HbA1c, ferritin, interleukin-6 (IL-6), C-reactive protein (CRP), and D-dimer levels at presentation and outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were altogether 47 eligible cases having a mean age of 48.8 \u00b1 10.9 years with a male:female ratio of 2.6:1; forty-two (89.4%) had pre-existing diabetes, and five (10.6%) had steroid-induced hyperglycemia. The mean HbA1c among diabetics was 9.7 \u00b1 2.1. HbA1c and serum CRP showed an increase over subsequent stages, which was not statistically significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.31). IL-6 values for all stages were similar (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.97). Only serum ferritin levels showed a statistically significant increase over stages (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04). IL-6 was significantly lower (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03) in patients who survived, whereas CRP levels were significantly lower in patients who had final visual acuity (VA) better than only perception of light (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Uncontrolled diabetes mellitus is a significant association of ROCM. Serum ferritin levels at presentation best correlate with extent of the disease. CRP levels are best to prognosticate cases that will have sufficient VA to carry on activities of daily living, whereas IL-6 levels are best associated with survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2507_22","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T03:34:06Z","timestamp":1684294446000},"page":"2193-2198","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Cross-sectional study to describe the severity, bio-chemical associations, and final outcomes of COVID-19-associated rhino-orbital-cerebral mucormycosis in a tertiary hospital of East India"],"prefix":"10.4103","volume":"71","author":[{"given":"Abhilasha","family":"Kumari","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Patna Medical College, Patna, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok","family":"Ranjan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Patna Medical College, Patna, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prateek","family":"Nishant","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, All India Institute of Medical Sciences, Patna, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sony","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Patna Medical College, Patna, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjeet K","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Patna Medical College, Patna, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"key":"R1-20251006","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3390\/microorganisms9030523","article-title":"Epidemiology of mucormycosis in India","volume":"9","author":"Prakash","year":"2021","journal-title":"Microorganisms"},{"key":"R2-20251006","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cmi.2018.07.011","article-title":"The epidemiology and clinical manifestations of mucormycosis:A systematic review and meta-analysis of case reports","volume":"25","author":"Jeong","year":"2019","journal-title":"Clin Microbiol Infect"},{"key":"R4-20251006","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1093\/mmy\/myu086","article-title":"A prospective study of mucormycosis in north India:Experience from a tertiary care hospital","volume":"53","author":"Bala","year":"2015","journal-title":"Med 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