{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:36:26Z","timestamp":1786649786539,"version":"build-2736575974"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Daily cleansing of eyelids is very important to carry out a successful blepharitis treatment. However, there are no therapeutic guidelines for blepharitis. The aim was to compare the symptomatic relief of anterior blepharitis using Blephamed eye gel, a cosmetic product, versus standard treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The study was a prospective, interventional open label clinical trial at a university-based hospital. The test population was subjects aged 18\u201365 years who presented with mild to moderate anterior blepharitis. Eyelid hygiene was applied twice a day. At each visit, a detailed assessment of symptomatology was carried out. A two-way repeated measure mixed model ANOVA was used to compare two groups by time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In total, 61 patients with mean age of 60.08 \u00b1 16.69 years were enrolled in the study including 30 patients in standard group and 31 patients in Blephamed group. Two groups did not differ in terms of age (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.31) and eye laterality (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.50). The baseline scores of erythema, edema, debris, and symptoms as well as total score were similar between two groups (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      values &gt;0.50). Two groups became different for all these parameters at day 45 (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      values &lt;0.001). Significant interaction was detected between time and intervention groups for all severity parameters of blepharitis as well as total score (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      values &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Eyelid hygiene with Blephamed more significantly decreased symptoms of anterior blepharitis compared to standard treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2546_22","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T03:34:55Z","timestamp":1684294495000},"page":"2188-2192","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of the effect of tea tree oil eye gel with standard treatment in patients with anterior blepharitis: An open-label clinical trial"],"prefix":"10.4103","volume":"71","author":[{"given":"Hossein","family":"Aghaei","sequence":"first","affiliation":[{"name":"Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behrouz","family":"Torabi","sequence":"additional","affiliation":[{"name":"Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parya","family":"Abdolalizadeh","sequence":"additional","affiliation":[{"name":"Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homa","family":"Vaghfipanah","sequence":"additional","affiliation":[{"name":"Eye Research Center, The Five 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