{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:42:57Z","timestamp":1786653777641,"version":"build-2736575974"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Compare the safety and efficacy of wavefront-guided photorefractive keratotomy (PRK) 6 months after cross-linking (CXL) to wavefront-guided PRK alone for refractive correction in patients with bilateral asymmetric corneal topography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Prospective randomized clinical trial with 16 patients (32 eyes). CXL with subsequent PRK after 6 months in one eye, and PRK alone was performed in contralateral eyes. The follow-up was 10 years. We analyzed visual outcomes, Scheimpflug topography, and corneal haze evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Eyes in the PRK group showed better results than in the CXL + PRK group. Mean postoperative CDVA was 0.044 logmar (SD, 0.073) in the PRK group and 0.1 logmar (SD, 0.21) in the CXL + PRK group, the mean sphere was + 0.21 (SD, 0.6) D in the PRK group and 0.87 (SD, 2.3) D in the CXL + PRK group, and mean SE was \u22120.35 (SD, 0.65) D in the PRK group and 0.62 (SD, 2.32) D in the CXL + PRK group. In one patient, a steepening of 2.5 D and a thinning of 17 \u00b5m occurred in PRK alone group. Two patients in the CXL + PRK group presented corneal haze. The overall complication rate was 18,75% (haze and ectasia).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Non-simultaneous CXL and PRK procedures yielded good refractive results, but worse than those obtained with PRK alone. Although one patient in the PRK group developed corneal ectasia, the CXL + PRK group had a higher loss of vision lines, indicating less safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2557_22","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T07:54:40Z","timestamp":1692604480000},"page":"3210-3218","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Ten-year follow-up of corneal cross-linking and refractive surface ablation in patients with asymmetric corneal topography"],"prefix":"10.4103","volume":"71","author":[{"given":"Bernardo Kaplan","family":"Moscovici","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Paulista School of Medicine\/Federal University of S\u00e3o Paulo (EPM\/UNIFESP), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo Felipe","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Paulista School of Medicine\/Federal University of S\u00e3o Paulo (EPM\/UNIFESP), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Paulo Suehiro","family":"Dantas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Paulista School of Medicine\/Federal University of S\u00e3o Paulo (EPM\/UNIFESP), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Taemy","family":"Okimoto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Paulista School of Medicine\/Federal University of S\u00e3o Paulo (EPM\/UNIFESP), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Obidulho Sakassegawa","family":"Naves","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Paulista School of Medicine\/Federal University of S\u00e3o Paulo (EPM\/UNIFESP), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Marques de Carvalho","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Paulista School of Medicine\/Federal University of S\u00e3o Paulo (EPM\/UNIFESP), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Baptista Nigro Santiago","family":"Malta","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Paulista School of Medicine\/Federal University of S\u00e3o Paulo (EPM\/UNIFESP), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Campos","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Paulista School of Medicine\/Federal University of S\u00e3o Paulo (EPM\/UNIFESP), S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"R1-20251008","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1016\/j.ophtha.2008.06.008","article-title":"Corneal ectasia after excimer laser keratorefractive surgery: Histopathology, ultrastructure, and pathophysiology","volume":"115","author":"Dawson","year":"2008","journal-title":"Ophthalmology"},{"key":"R2-20251008","first-page":"2434830","article-title":"Risk assessment for corneal ectasia following photorefractive keratectomy","author":"Sorkin","year":"2017","journal-title":"J Ophthalmol 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History"}},{"value":"2023-06-12","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}