{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:29:03Z","timestamp":1788478143932,"version":"build-2803163510"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To study the demographics and clinical profile of keratoconus (KC) presenting in pre-teen children in India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a retrospective case series conducted as a single-institutional study at a tertiary eye center in India. A total of 586 eyes from 294 KC patients (aged 12 years or less) without any active comorbid conditions of the eye were included in the study. Slit-lamp biomicroscopy was used to document the clinical signs of KC. Information on age; gender; reason for consultation; family history; history of allergy, atopy, and eye rubbing; manifest refraction; uncorrected and best-corrected distance visual acuity (UCVA and BCVA, respectively); clinical presentation; and contact lens usage were also analyzed, along with data on types of medical and surgical treatments for KC and their outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean age of this pediatric KC patient cohort was 9.3 \u00b1 1.8 years, and there was a male (70%) preponderance. Baseline mean UCVA, BCVA, steep keratometry, and flat keratometry were 0.86 \u00b1 0.58 logMAR, 0.44 \u00b1 0.38 logMAR, 54.82 \u00b1 8.4 D, and 48.21 \u00b1 9.5 D, respectively. Progression, necessitating collagen crosslinking (CXL), was noted in 12.7% eyes. Post-CXL, visual and topographic parameters remained stable without any complications till 6 months posttreatment. However, in eyes that did not undergo CXL, significant progression over time (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) was observed. A keratoplasty was required in 2.3% eyes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>KC was present at an advanced stage in 25% of the pre-teens in our series, and therefore, it is an important diagnostic entity when a refractive error is diagnosed, even in very young children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2579_21","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T11:10:13Z","timestamp":1665054613000},"page":"3508-3513","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":18,"title":["Keratoconus in pre-teen children: Demographics and clinical profile"],"prefix":"10.4103","volume":"70","author":[{"given":"Bhava","family":"Tharini","sequence":"first","affiliation":[{"name":"Cornea Institute, LV Prasad Eye Institute, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srujana","family":"Sahebjada","sequence":"additional","affiliation":[{"name":"Centre for Eye Research Australia, Melbourne, Australia"},{"name":"Department of Surgery, Ophthalmology, The University of Melbourne, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Agustina","family":"Borrone","sequence":"additional","affiliation":[{"name":"Cornea Institute, LV Prasad Eye Institute, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pravin","family":"Vaddavalli","sequence":"additional","affiliation":[{"name":"Cornea Institute, LV Prasad Eye Institute, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasnat","family":"Ali","sequence":"additional","affiliation":[{"name":"Cornea Institute, LV Prasad Eye Institute, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagadesh 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