{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:04:24Z","timestamp":1787069064771,"version":"build-2736575974"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate and compare the efficacy of autologous platelet-rich plasma (aPRP) eye drop and artificial tear (AT) eye drop in moderate to severe symptomatic dry eye disease (DED).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This prospective interventional study included 121 eyes of 61 patients of moderate to severe DED. Patients were divided into aPRP (31 patients) and AT (30 patients) group. Ocular Surface Disease Index (OSDI) score, tear film breakup time (TBUT) (s), corneal fluorescein staining (CFS) score, and Schirmer test score (mm) of both the groups were evaluated and compared pre-treatment and post-treatment at the end of 3 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean age of the aPRP group and AT group was 52.8 \u00b1 12.8 years and 55.5 \u00b1 13.4 years, respectively. At the end of 3 months, OSDI score reduced more in the aPRP group as compared to AT group, and the mean difference (\u221222.7) was statistically significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). There was no significant difference in post-treatment Schirmer test score between the two groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.44). Post-treatment improvement in TBUT and CFS score in the aPRP group was significantly higher in the aPRP group as compared to that in the AT group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). Bruising at the site of blood withdrawal was noted in two patients in the aPRP group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>aPRP is safe and more effective than AT in treating patients with moderate to severe symptomatic DED.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2595_21","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T06:53:23Z","timestamp":1652252003000},"page":"1549-1553","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":17,"title":["Autologous platelet-rich plasma eye drop versus artificial tear eye drop for symptomatic dry eye disease: A prospective comparative interventional study"],"prefix":"10.4103","volume":"70","author":[{"given":"Preeti","family":"Rawat","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Mahatma Gandhi Memorial Medical College, M. Y. Hospital, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritika","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Mahatma Gandhi Memorial Medical College, M. Y. Hospital, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Bhaisare","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Mahatma Gandhi Memorial Medical College, M. Y. Hospital, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Walia","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Mahatma Gandhi Memorial Medical College, M. Y. Hospital, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neetu","family":"Kori","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Mahatma Gandhi Memorial Medical College, M. Y. Hospital, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Mahatma Gandhi Memorial Medical College, M. Y. 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