{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:54:32Z","timestamp":1789505672081,"version":"build-2803163510"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Glaucoma is the second leading cause of blindness worldwide, affecting more than 64 million people aged 40\u201380. The best way to manage primary open-angle glaucoma (POAG) is by lowering the intraocular pressure (IOP). Netarsudil is a Rho kinase inhibitor, the only class of antiglaucoma medications that reorganizes the extracellular matrix to improve the aqueous outflow through the trabecular pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>An open-label, real-world, multicentric, observation-based 3-month study was performed for assessing the safety and ocular hypotensive efficacy of netarsudil ophthalmic solution (0.02% w\/v) in patients with elevated IOP. Patients were given netarsudil ophthalmic solution (0.02% w\/v) as a first-line therapy. Diurnal IOP measurements, best-corrected visual acuity, and adverse event assessments were recorded at each of the five visits (Day-1: screening day and first dosing day; subsequent observations were taken at 2 weeks, 4 weeks, 6 weeks, and 3 months).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Four hundred and sixty-nine patients from 39 centers throughout India completed the study. The mean IOP at baseline of the affected eyes was 24.84 \u00b1 6.39 mmHg (mean \u00b1 standard deviation). After the first dose, the IOP was measured after 2, 4, and 6 weeks, with the final measurement taken at 3 months. The percentage reduction in IOP in glaucoma patients after 3 months of once-daily netarsudil 0.02% w\/v solution use was 33.34%. The adverse effects experienced by patients were not severe in the majority of cases. Some adverse effects observed were redness, irritation, itching, and others, but only a small number of patients experienced severe reactions, as reported in a decreasing order: redness &gt; irritation &gt; watering &gt; itching &gt; stinging &gt; blurring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We found that netarsudil 0.02% w\/v solution monotherapy when used as the first-line treatment in primary open-angle glaucoma and ocular hypertension was both safe and effective.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_25_23","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T09:03:19Z","timestamp":1686733399000},"page":"2500-2503","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Netarsudil monotherapy as the initial treatment for open-angle glaucoma and ocular hypertension in Indian patients: A real-world evaluation of efficacy and safety"],"prefix":"10.4103","volume":"71","author":[{"given":"Manoj Chandra","family":"Mathur","sequence":"first","affiliation":[{"name":"Swarup Eye Centre, Swarup Eye Centre, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Venkat","family":"Ratnam","sequence":"additional","affiliation":[{"name":"Sarojini Devi Eye Hospital, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.J.","family":"Saikumar","sequence":"additional","affiliation":[{"name":"Giridhar Eye Institute, Kochi, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"John","sequence":"additional","affiliation":[{"name":"Holy Ghost Mission Hospital, Kottayam, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharth","family":"Ravishankar","sequence":"additional","affiliation":[{"name":"Dr. Ravi Shankar Eye Clinic, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.B","family":"Dinesh","sequence":"additional","affiliation":[{"name":"Uma Eye Clinic, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Chandil","sequence":"additional","affiliation":[{"name":"Sushrutha Eye Hospital, Mysuru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishore","family":"Pahuja","sequence":"additional","affiliation":[{"name":"Natasha Eye Care and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidya","family":"Cherlikar","sequence":"additional","affiliation":[{"name":"H.V. Desai Hospital, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunny","family":"Wadhwani","sequence":"additional","affiliation":[{"name":"Divya Jyot Eye Care, Akola, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Bendale","sequence":"additional","affiliation":[{"name":"Dr. Bendale\u2019s Eye Care, Pimpri-Chinchwad, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit","family":"Hazari","sequence":"additional","affiliation":[{"name":"Hazari Nursing Home, Aurangabad, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Mishra","sequence":"additional","affiliation":[{"name":"Advanced Eye Hospital, A Unit of Dr Agarwals Eye Hospital, Vashi, Navi Mumbai, Maharashtra, 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Sharma Eye Hospital, Ambala, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev","family":"Gupta","sequence":"additional","affiliation":[{"name":"Sangam Netralya, Mohali, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,6,14]]},"reference":[{"key":"R1-20251006","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ajo.2019.03.002","article-title":"Once-daily netarsudil versus twice-daily timolol in patients with elevated intraocular pressure:The randomised phase 3 ROCKET-4 study","volume":"204","author":"Khouri","year":"2019","journal-title":"Am J Ophthalmol"},{"key":"R2-20251006","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040:A systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"R4-20251006","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1089\/jop.2017.0138","article-title":"The effects of netarsudil ophthalmic solution on aqueous humor dynamics in a andomized study in humans","volume":"34","author":"Kazemi","year":"2018","journal-title":"J Ocul Pharmacol Ther"},{"key":"R6-20251006","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1177\/1060028020971215","article-title":"Netarsudil for the treatment of open-angle glaucoma and ocular hypertension:A literature review","volume":"55","author":"Gonzalez","year":"2021","journal-title":"Ann Pharmacother"},{"key":"R7-20251006","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.18203\/2319-2003.ijbcp20184263","article-title":"Netarsudil:A novel intra-ocular pressure lowering agent","volume":"7","author":"Ghanghas","year":"2018","journal-title":"Int J Basic Clin Pharmacol"},{"key":"R8-20251006","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ajo.2021.01.019","article-title":"Netarsudil improves trabecular outflow facility in patients with primary open angle glaucoma or ocular hypertension:A phase 2 study","volume":"226","author":"Sit","year":"2021","journal-title":"Am J Ophthalmol"},{"key":"R9-20251006","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1080\/03007995.2021.1901222","article-title":"A multicenter, open-label study of netarsudil for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension in a real-world setting","volume":"37","author":"Zaman","year":"2021","journal-title":"Curr Med Res Opin"},{"key":"R10-20251006","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1097\/IJG.0000000000001634","article-title":"Pooled efficacy and safety profile of netarsudil ophthalmic solution 0.02% in patients with open-angle glaucoma or ocular hypertension","volume":"29","author":"Singh","year":"2020","journal-title":"J Glaucoma"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_25_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:57:26Z","timestamp":1786647446000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_25_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_25_23","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"2023-01-03","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-21","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}