{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:38:55Z","timestamp":1789753135578,"version":"4.0.1"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Fraser syndrome is a rare congenital disorder comprising cryptophthalmos, syndactyly, and many times, urogenital anomalies. Herein, the authors aimed to study and report the clinical features and orbital anomalies in cases diagnosed with Fraser syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The authors retrospectively evaluated the records of patients with Fraser syndrome who had presented to a tertiary eye care hospital in northern India in the last 2 years (from January 2019 to December 2020). The clinical features were studied, entered in MS Excel, and the data was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Data of 15 patients with Fraser syndrome were found. Majority of the patients were males and presented in the pediatric age group. Bilateral involvement was more common, and the most common variant of cryptophthalmos was abortive. Complete and medial madarosis of the eyebrows was the most common periocular finding. Complete cryptophthalmos was associated with cystic globes, whereas abortive forms had superior symblepharon. Common systemic features included syndactyly, bifid nose, and urogenital anomaly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Fraser syndrome is an extremely rare developmental disorder; it encompasses a wide range of ocular, periocular, and orbital anomalies, along with multiple pre-existing systemic anomalies. The treating ophthalmologist should always be careful in examining these patients<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2627_21","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T06:28:32Z","timestamp":1657607312000},"page":"2559-2563","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Clinical features and orbital anomalies in Fraser syndrome and a review of management options"],"prefix":"10.4103","volume":"70","author":[{"given":"Deepsekhar","family":"Das","sequence":"first","affiliation":[{"name":"Department of Oculoplasty and Orbital Tumor Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujeeth","family":"Modaboyina","sequence":"additional","affiliation":[{"name":"Department of Oculoplasty and Orbital Tumor Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandton","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Oculoplasty and Orbital Tumor Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahil","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Oculoplasty and Orbital Tumor Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandeep Singh","family":"Bajaj","sequence":"additional","affiliation":[{"name":"Department of Oculoplasty and Orbital Tumor Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"B1-20240828","first-page":"224","article-title":"Eine Missegeburt mit hautuberwachsenen Augen oder Kryptophthalmos","volume":"10","author":"Zehender","year":"1872","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"B2-20240828","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1017\/S1120962300012294","article-title":"Malformative syndrome with cryptophthalmos","volume":"18","author":"Francois","year":"1969","journal-title":"Acta Genet Med Gemellol"},{"key":"B3-20240828","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1136\/jmg.39.9.623","article-title":"Fraser syndrome and cryptophthalmos:A review of the diagnostic criteria and evidence of phenotypic modules","volume":"39","author":"Slavotinek","year":"2002","journal-title":"J Med Genet"},{"key":"B4-20240828","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1469-1809.1962.tb01774.x","article-title":"Our genetical 'load'. A review of some aspects of genetical variation","volume":"25","author":"Fraser","year":"1962","journal-title":"Ann Hum Genet"},{"key":"B5-20240828","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1002\/ajmg.a.31951","article-title":"Fraser Syndrome Collaboration Group, Hennekam RCM. 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