{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T19:50:31Z","timestamp":1793303431045,"version":"4.5.0"},"reference-count":123,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>\n                    This is a comprehensive review after a thorough literature search in PubMed-indexed journals, incorporating current information on the pathophysiology, clinical features, diagnosis, medical and surgical therapy, as well as outcomes of\n                    <jats:italic toggle=\"yes\">Acanthamoeba<\/jats:italic>\n                    keratitis (AK). AK is a significant cause of ocular morbidity, and early diagnosis with timely institution of appropriate therapy is the key to obtaining good outcomes. The varied presentations result in frequent misdiagnosis, and co-infections can increase the morbidity of the disease. The first line of therapy continues to be biguanides and diamidines, with surgery as a last resort.\n                  <\/jats:p>","DOI":"10.4103\/ijo.ijo_2627_23","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T04:02:25Z","timestamp":1709870545000},"page":"473-482","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":38,"title":["Acanthamoeba keratitis \u2013 A review"],"prefix":"10.4103","volume":"72","author":[{"given":"Anita","family":"Raghavan","sequence":"first","affiliation":[{"name":"Cornea & Refractive Surgery, Department of Microbiology, Aravind Eye Hospital and Post-Graduate Institute of Ophthalmology, Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram","family":"Rammohan","sequence":"additional","affiliation":[{"name":"Cornea & Refractive Surgery, Department of Microbiology, Aravind Eye Hospital and Post-Graduate Institute of 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