{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:12:34Z","timestamp":1791087154472,"version":"4.1.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Real-life comparison of three intravitreal drug regimens used in cases of endophthalmitis at a tertiary care center in India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this prospective, comparative study, patients of bacterial endophthalmitis were grouped according to intravitreal antibiotic drug regimens into Group 1 (ceftazidime and vancomycin), Group 2 (piperacillin + tazobactam and vancomycin), and Group 3 (imipenem and vancomycin). Forty-eight hours after injection nonresponding\/worsening patients underwent vitrectomy. Vitreous samples were subjected to microbiological and pharmacokinetic tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 64 patients were included and divided into Group 1: 29, Group 2: 20, and Group 3: 15 cases. Also, 75% of patients were post-surgical endophthalmitis, whereas 25% were post-traumatic. Improvement in vision (V\n                      <jats:sub>90-0<\/jats:sub>\n                      ) and vision at 3 months (V\n                      <jats:sub>90<\/jats:sub>\n                      ) were comparable between the three groups. Visual recovery was poorer in post-traumatic cases. In post-surgical cases, visual recovery was poorer in those presenting beyond 72 h of onset of symptoms (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0002). Polymerase chain reaction (PCR) positivity (66%) was higher than BACTEC\u2122 (33%) and culture (14%). Antibiotic resistance was comparable amongst the three groups. Most patients (62\/64) further underwent vitrectomy. Ceftazidime and vancomycin achieved vitreous concentrations more than the minimum inhibitory concentration (MIC) at 48 h after the first injection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The choice of antibiotics did not affect the rate of vitrectomy and final vision in a real-life scenario. Ceftazidime and vancomycin can still be used as first-line intravitreal antibiotics owing to their comparable microbial sensitivity profile and adequate ocular bioavailability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2640_21","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T06:53:23Z","timestamp":1652252003000},"page":"1696-1700","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Real-life comparison of three intravitreal antibiotic drug regimens in endophthalmitis"],"prefix":"10.4103","volume":"70","author":[{"given":"Aafreen","family":"Bari","sequence":"first","affiliation":[{"name":"Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Chawla","sequence":"additional","affiliation":[{"name":"Dr Rajendra Prasad 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