{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:50:25Z","timestamp":1791359425685,"version":"4.3.1"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To investigate the relationship between systemic hypertension, ocular perfusion pressure (OPP), and intraocular pressure (IOP) with glaucoma severity, with a secondary analysis on the impact of antihypertensive medication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Cross-sectional observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 75 patients (75 eyes) with primary open-angle glaucoma (POAG) were included. One eye per patient was randomly selected for analysis. All participants underwent comprehensive ophthalmic examination and a single time-point systemic blood pressure (BP) measurement. Data on antihypertensive medication usage were also collected. Glaucoma was staged as early, moderate, or advanced. Key variables included systolic\/diastolic blood pressure (SBP\/DBP), mean arterial pressure (MAP), IOP, and estimated OPP. Analysis of variance and Pearson\u2019s correlation were used. A sub-group analysis compared hemodynamic parameters between patients on antihypertensive medication and those who were not.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean age was 53.99 \u00b1 6.53 years. While mean IOP did not differ significantly across glaucoma stages (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.71), mean OPP (57.59 to 50.65 mmHg), diastolic perfusion pressure (DPP), DBP, and MAP all decreased significantly with increasing glaucoma severity (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). In a sub-group analysis, patients on antihypertensive medication (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 42) had a significantly lower mean OPP (53.21 \u00b1 5.98 mmHg) compared to those not on medication (57.85 \u00b1 5.89 mmHg;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002), despite having similar in-office SBP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Lower OPP, DPP, DBP, and MAP were significantly associated with advanced glaucoma severity. Patients on antihypertensive medication had lower mean OPP, suggesting they may be at higher risk for perfusion-related damage not captured by in hospital BP readings. This highlights the importance of considering the hemodynamic effects of medication in glaucoma management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2650_25","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:03:56Z","timestamp":1790690636000},"page":"1514-1517","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["The association of lower ocular perfusion pressure with glaucoma severity independent of intraocular pressure"],"prefix":"10.4103","volume":"74","author":[{"given":"Narasimha","family":"Mukkamala","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Asram Medical College, Eluru, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Pakalapati","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Asram Medical College, Eluru, Andhra Pradesh, 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