{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:01:06Z","timestamp":1793134866179,"version":"4.5.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the prognostic potential of systemic inflammatory index in the course of retinopathy of prematurity (ROP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This is a retrospective case-control study. 303 infants with a gestational age of \u226435 weeks were screened with and without ROP at birth and 1 month after the birth of complete blood counts (CBC) were included in this study. Serum neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte (PLR), and systemic immune-inflammation index (SII) was calculated at birth and one month after. LMR was calculated by dividing the absolute lymphocyte count by the absolute monocyte count. NLR and PLR were determined by dividing the absolute neutrophil count or the absolute platelet count by the absolute lymphocyte count, respectively. The SII was calculated by the formula = neutrophilxplatelet\/lymphocyte. All statistical analyses were performed using SPSS 22 (SPSS for Windows, version 22.0; SPSS, Inc. Chicago, IL, USA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 303 infants were included 145 with ROP and 158 without ROP. The NLR, LMR, PLR and SII values were 0.56 \u00b1 1.17\/0.51 \u00b1 1.04 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.997), 13.7 \u00b1 18\/9.49 \u00b1 13.1 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.014), 31.69 \u00b1 68\/24.1 \u00b1 37.7 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.268), 131.42 \u00b1 326\/124.66 \u00b1 267 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.935) in with ROP and without ROP infant at birth respectively. The NLR, LMR, PLR, and SII values were 0.68 \u00b1 1.27\/0.34 \u00b1 0.99 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001), 2.58 \u00b1 6.01\/2.46 \u00b1 14.5 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.706), 47.5 \u00b1 78.33\/33.55 \u00b1 42.4 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.035), and 253 \u00b1 681\/114 \u00b1 345 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001), respectively in with ROP and without ROP infant at 1 month after birth.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The NLR, PLR, and SII seem an independent predictor of the development of ROP.<\/jats:p>\n                  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