{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:27:20Z","timestamp":1786728440434,"version":"build-2736575974"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11]]},"abstract":"\n Purpose:<\/jats:title>\n The objective of this study was to find the association between fetal hemoglobin (HbF) concentration and retinopathy of prematurity (ROP) in preterm infants.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n In this observational, prospective, longitudinal study, a total of 410 preterm infants with <36 gestational weeks and <2.5 kg birth weight, who were attending ROP clinic in a tertiary care hospital of central India for 1 year duration were included. Dilated fundus examination was done as per ROP screening guidelines, and ROP was staged as per international classification for retinopathy of prematurity (ICROP) classification, 2021. HbF (%) was measured with high-performance liquid chromatography, and data was analyzed statistically. The relationship between HbF (%) and ROP was evaluated. Those infants who had ROP were further divided into treatment-requiring and non\u2013treatment-requiring groups and HbF was compared in these groups at the first visit and after 1-month follow-up period. The outcome of ROP was studied with HbF levels.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n A total of 410 preterm infants were included, out of which 110 infants had ROP (26.8%). Infants with ROP had significantly lower percentage of HbF with gestational age groups and birth weight groups, compared to infants without ROP. Higher percentage of HbF was associated with a lower prevalence of ROP. Higher concentration of HbF was found in the ROP infants who regressed spontaneously without treatment and less concentration was found in those who progressed to a severe disease and those who required treatment. The predictive ability of HbF (%) was 0.976 for ROP.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Low fraction of HbF was found to be significantly associated with the development and progression of ROP.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijo.ijo_274_23","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T11:19:33Z","timestamp":1697800773000},"page":"3478-3483","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":16,"title":["Role of fetal hemoglobin in the development and progression of retinopathy of prematurity in preterm infants"],"prefix":"10.4103","volume":"71","author":[{"given":"Nishi","family":"Prasad","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Gandhi Medical College, Bhopal, Madhya Pradesh, 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