{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:23:41Z","timestamp":1787840621494,"version":"build-2784847793"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To investigate the change in ocular parameters of anisomyopic children treated with 0.01% atropine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective study analyzed the data of anisomyopic children who underwent comprehensive examination at a tertiary eye center in India. Anisomyopic subjects (difference of \u22651.00 D) of age 6\u201312 years who were treated with 0.01% atropine or prescribed regular single vision spectacle and had follow-ups of more than 1 year were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Data from 52 subjects were included. No difference was observed in the mean rate of change of spherical equivalent (SE) of more myopic eyes between 0.01% atropine (\u22120.56 D; 95% confidence interval [CI]: \u22120.82, \u22120.30) and single vision lens wearers (\u22120.59 D; 95% CI: \u22120.80, \u22120.37;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.88). Similarly, insignificant change in the mean SE of less myopic eyes was noted between the groups (0.01% atropine group, \u22120.62 D; 95% CI: \u22120.88, \u22120.36 vs. single vision spectacle wearer group, \u22120.76 D; 95% CI: \u22121.00, \u22120.52;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.43). None of the ocular biometric parameters showed any difference between the two groups. Though anisomyopic cohort treated with 0.01% atropine revealed a significant correlation between the rate of change of mean SE and axial length in both eyes (more myopic eyes,\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = \u22120.58;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001 and less myopic eyes,\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = \u22120.82;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) compared to single vision spectacle wearer group, the change was not significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Administration of 0.01% atropine had minimal effect on reducing the rate of myopia progression in anisomyopic eyes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2762_22","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T03:11:32Z","timestamp":1684293092000},"page":"2109-2114","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness of 0.01% atropine in anisomyopic children"],"prefix":"10.4103","volume":"71","author":[{"given":"Azfira","family":"Hussain","sequence":"first","affiliation":[{"name":"Myopia Clinic, Unit of Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Gopalakrishnan","sequence":"additional","affiliation":[{"name":"Myopia Clinic, Unit of Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurav","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Myopia Clinic, Unit of Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumita","family":"Agarkar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Ophthalmology, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"key":"R1-20251006","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0042-6989(62)90062-7","article-title":"The optical components in anisometropia","volume":"2","author":"Sorsby","year":"1962","journal-title":"Vision Res"},{"key":"R2-20251006","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1097\/OPX.0b013e318233ee5f","article-title":"Interocular symmetry in myopic 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