{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:29:34Z","timestamp":1787758174426,"version":"build-2784847793"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,8]]},"abstract":"\n Purpose:<\/jats:title>\n To analyze the 5-year results of accelerated corneal collagen crosslinking (CXL) for progressive keratoconus and identify preoperative characteristics predictive of visual and topographic outcomes.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n A prospective interventional case series. Nineteen eyes of 19 patients receiving accelerated CXL with settings of 18 mW\/cm\n 2<\/jats:sup>\n for 5 min were included. Clinical and topographic parameters were assessed. Linear regression and logistic regression were used to compare the R\n 2<\/jats:sup>\n and odds ratio (OR), respectively, between baseline characteristics and postoperative outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Corrected distance visual acuity (CDVA) remained stable from 0.28 \u00b1 0.21 to 0.25 \u00b1 0.18 logMAR (\n P<\/jats:italic>\n = 0.486). The mean cylindrical refraction was stable (\n P<\/jats:italic>\n = 0.119). The maximal keratometry (Kmax) decreased from 61.99 \u00b1 10.37 to 59.25 \u00b1 7.75 D (\n P<\/jats:italic>\n < 0.001), flattening in the flattest and steepest meridians and mean keratometry were also observed (\n P<\/jats:italic>\n \u2264 0.040). The mean anterior elevation at the apex reduced from 21.42 \u00b1 16.69 to 18.53 \u00b1 12.74 mm (\n P<\/jats:italic>\n = 0.013) and changes in posterior elevation were non-significant (\n P<\/jats:italic>\n = 0.629). Preoperative Kmax best predicted the postoperative change in Kmax (R\n 2<\/jats:sup>\n = 0.55,\n P<\/jats:italic>\n < 0.001) compared to the other baseline characteristics (\n P<\/jats:italic>\n \u2264 0.028), whereas preoperative CDVA was the only significant predictor of postoperative change in CDVA (R\n 2<\/jats:sup>\n = 0.41,\n P<\/jats:italic>\n = 0.003). Accelerated CXL is less likely to fail in eyes with a steeper preoperative Kmax (OR = 0.74,\n P<\/jats:italic>\n = 0.040) or greater posterior elevation at the apex (OR = 0.91,\n P<\/jats:italic>\n = 0.042).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Kmax significantly decreased following accelerated CXL. Eyes with worse preoperative CDVA and higher Kmax were more likely to have an improvement in visual acuity and corneal flattening.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2778_21","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T11:45:11Z","timestamp":1659613511000},"page":"2930-2935","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":15,"title":["Accelerated corneal collagen cross-linking in progressive keratoconus: Five-year results and predictors of visual and topographic outcomes"],"prefix":"10.4103","volume":"70","author":[{"given":"Tommy C Y","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong"},{"name":"Department of Ophthalmology, Hong Kong Sanatorium and Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel W Y","family":"Tsui","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong"},{"name":"Hong Kong Eye Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanissa W S","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong"},{"name":"Hong Kong Eye Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine K M","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong"},{"name":"Hong Kong Eye Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria W Y","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong"},{"name":"Hong Kong Eye Hospital, Hong Kong"},{"name":"LKS Faculty of Medicine, The University of Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin H","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong"},{"name":"Hong Kong Eye Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,7,29]]},"reference":[{"key":"B1-20240828","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.ophtha.2013.10.028","article-title":"A randomized, controlled trial of corneal collagen cross-linking in progressive keratoconus:Three-year 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