{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:35:11Z","timestamp":1786649711968,"version":"build-2736575974"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate Vitamin B12 levels in healthcare professionals at a tertiary eyecare centre in India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a cross-sectional study conducted among healthcare professionals working at a tertiary eyecare centre in India. The sample included 2,374 employees. Chemiluminescent immunoassay method (reference range, 211\u2013911 pg\/ml) was used to assess serum vitamin B12 levels. Effect of age and gender was analyzed in vitamin B12 normal and vitamin B12 deficient groups. To evaluate risk factors, questions related to vitamin B12 deficiency were asked to the study participants in a survey.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean age of employees was 29.2 \u00b1 0.7 years. Around 26% of them were vitamin B12 deficient. The proportion of males in the vitamin B12 deficient group (61.2%) was significantly higher (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001) than that of the vitamin B12 normal group (44.9%). There was no effect of age on vitamin B12 levels in both vitamin B12 normal and vitamin B12 deficient groups. Mean vitamin B12 levels in males (289.1 \u00b1 22.2 pg\/ml) was significantly lower (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001) than that of females (338.7 \u00b1 30.0 pg\/ml).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This is the first such study on eyecare professionals. One-fourth of the eyecare professionals were vitamin B12 deficient. The proportion of males was higher in the vitamin B12 deficiency group. Males had lower vitamin B12 levels than females. Annual blood tests for vitamin B12 are recommended for timely diagnosis and management of vitamin B12 deficiency, particularly in males.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2823_21","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T06:53:23Z","timestamp":1652252003000},"page":"1718-1721","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Vitamin B12 deficiency in a large cohort of healthcare professionals across the network of an eyecare organization in India"],"prefix":"10.4103","volume":"70","author":[{"given":"Sushma","family":"Nandyala","sequence":"first","affiliation":[{"name":"Ophthalmic Biophysics, L V Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashik","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Ophthalmic Biophysics, L V Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Bhargava","sequence":"additional","affiliation":[{"name":"Internal Medicine, L V Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Chaurasia","sequence":"additional","affiliation":[{"name":"The Cornea Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirisha","family":"Senthil","sequence":"additional","affiliation":[{"name":"VST Centre for Glaucoma Care, L V Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pravin K","family":"Vaddavalli","sequence":"additional","affiliation":[{"name":"The Cornea Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,4,28]]},"reference":[{"key":"R1-20251006","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1177\/15648265080292S107","article-title":"Review of the magnitude of folate and vitamin B12 deficiencies worldwide","volume":"29","author":"McLean","year":"2008","journal-title":"Food Nutr Bull"},{"key":"R2-20251006","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/ejcn.2014.46","article-title":"The prevalence of cobalamin deficiency among vegetarians assessed by serum vitamin B12: A review of literature","volume":"68","author":"Pawlak","year":"2014","journal-title":"Eur J Clin Nutr"},{"key":"R3-20251006","doi-asserted-by":"crossref","first-page":"e100379","DOI":"10.1371\/journal.pone.0100379","article-title":"Vitamin B12 status in metformin treated patients: Systematic review","volume":"9","author":"Liu","year":"2014","journal-title":"PLoS One"},{"key":"R4-20251006","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.3945\/jn.109.114751","article-title":"Community-level micronutrient fortification of school lunch meals improved vitamin A folate, and iron status of schoolchildren in Himalayan villages of India","volume":"140","author":"Osei","year":"2010","journal-title":"J Nutr"},{"key":"R5-20251006","first-page":"536","article-title":"Vitamin B12 and health","volume":"54","author":"Ryan-Harshman","year":"2008","journal-title":"Can Fam Physician"},{"key":"R6-20251006","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1056\/NEJMcp1113996","article-title":"Clinical practice. 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