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These include but are not limited to serum angiotensin-converting enzyme (ACE), lysozyme, plain-film radiographs of the chest, computed tomography (CT) scans of the chest, pulmonary function testing, bronchoalveolar lavage, and retinal imaging among others. In this review, we highlight current and evolving systemic investigations and approaches to ophthalmic imaging when considering the diagnosis of ocular sarcoidosis.<\/jats:p>","DOI":"10.4103\/ijo.ijo_2830_21","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T07:53:23Z","timestamp":1648454003000},"page":"1121-1129","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":10,"title":["Progress in the diagnosis of ocular sarcoidosis"],"prefix":"10.4103","volume":"70","author":[{"given":"Ghazala A Datoo","family":"O\u2019Keefe","sequence":"first","affiliation":[{"name":"Emory University School of Medicine, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narsing A","family":"Rao","sequence":"additional","affiliation":[{"name":"USC Keck School of Medicine, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,3,22]]},"reference":[{"key":"B1-20240828","first-page":"1","article-title":"Clinical characteristics of ocular sarcoidosis: A population-based study 1976\u20132013","volume":"27","author":"Ungprasert","year":"2017","journal-title":"Ocul Immunol Inflamm"},{"key":"B2-20240828","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0002-9394(86)90001-2","article-title":"Ocular involvement in chronic sarcoidosis","volume":"102","author":"Jabs","year":"1986","journal-title":"Am J Ophthalmol"},{"key":"B3-20240828","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.2147\/OPTH.S278373","article-title":"Ocular manifestations of sarcoidosis in a South Florida population","volume":"14","author":"Laura","year":"2020","journal-title":"Clin Ophthalmol"},{"key":"B4-20240828","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1136\/bjo.84.1.110","article-title":"Ocular involvement in sarcoidosis","volume":"84","author":"Rothova","year":"2000","journal-title":"Br J Ophthalmol"},{"key":"B5-20240828","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1001\/archopht.1961.01840020455023","article-title":"Sarcoid of the fundus","volume":"65","author":"Gould","year":"1961","journal-title":"Arch Ophthalmol"},{"key":"B6-20240828","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/0002-9394(78)90184-8","article-title":"Sarcoidosis and its ophthalmic manifestations","volume":"86","author":"Obenauf","year":"1978","journal-title":"Am J Ophthalmol"},{"key":"B7-20240828","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1080\/09273940802687812","article-title":"Ocular features in neurosarcoidosis","volume":"17","author":"Menezo","year":"2009","journal-title":"Ocul Immunol Inflamm"},{"key":"B8-20240828","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1080\/09273940902818861","article-title":"members of Scientific Committee of First International Workshop on Ocular Sarcoidosis. 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