{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:32:28Z","timestamp":1792211548944,"version":"4.4.0"},"reference-count":70,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>The incidence of ocular graft versus host disease (oGVHD) is rising due to the increasing numbers of bone marrow transplantations for various hematologic malignancies and non-malignant indications. The ophthalmic aspect of graft versus host disease (GVHD) still requires much understanding. We carried out a PubMed search of all articles using the terms \u201coGVHD,\u201d \u201cdry eye + hematopoietic stem cell transplantation (HSCT),\u201d \u201cacute GVHD,\u201d and \u201cChronic GVHD.\u201d The review mainly focuses on the existing lacunae in terms of diagnostic criteria. Diagnosis of ocular involvement in GVHD follows the criteria described by the National Institute of Health Consensus Conference (NIH CC) or International Chronic oGVHD (ICCGCHD) consensus group. The severity grading of oGVHD is by Jab\u2019s or Robinson\u2019s grading for conjunctival involvement. NIH CC and ICCGVHD remain the most commonly used scoring systems. Management of ocular involvement during acute GVHD remains challenging, whereas chronic oGVHD in its milder forms mainly manifests as dry eye disease and is treated accordingly. Multiple unanswered questions remain regarding this entity\u2019s pathogenesis, diagnostic criteria, and clinical features. Large-scale prospective studies involving oncologists and ophthalmologists must answer questions and formulate guidelines.<\/jats:p>","DOI":"10.4103\/ijo.ijo_2839_22","type":"journal-article","created":{"date-parts":[[2023,4,8]],"date-time":"2023-04-08T11:10:52Z","timestamp":1680952252000},"page":"1115-1122","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":12,"title":["A brief account on ocular graft versus host disease"],"prefix":"10.4103","volume":"71","author":[{"given":"Debapriya","family":"Chatterjee","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Acharya Shri Chander College of Medical Sciences and Hospital, Sidhra, Jammu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,4,5]]},"reference":[{"key":"R1-20240828","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1182\/blood-2016-07-686642","article-title":"Classification systems for chronic graft-versus-host disease","volume":"129","author":"Lee","year":"2017","journal-title":"Blood"},{"key":"R2-20240828","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1136\/bjophthalmol-2011-300514","article-title":"Comparison of stem cell sources in the severity of dry eye after allogeneic haematopoietic stem cell transplantation","volume":"96","author":"Uchino","year":"2012","journal-title":"Br J Ophthalmol"},{"key":"R3-20240828","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1016\/S0161-6420(01)00675-3","article-title":"Phacoemulsification in patients after allogeneic bone marrow transplantation","volume":"108","author":"Balaram","year":"2001","journal-title":"Ophthalmology"},{"key":"R4-20240828","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1038\/bmt.2015.187","article-title":"Incidence and risk factors for ocular GVHD after allogeneic hematopoietic stem cell transplantation","volume":"50","author":"Na","year":"2015","journal-title":"Bone Marrow Transplant"},{"key":"R5-20240828","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jtos.2018.04.001","article-title":"Ocular chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation in an Italian referral center","volume":"16","author":"Berchicci","year":"2018","journal-title":"Ocul Surf"},{"key":"R6-20240828","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/sj.bmt.1705490","article-title":"Chronic graft-versus-host disease:Implications of the National Institutes of Health consensus development project on criteria for clinical trials","volume":"38","author":"Pavletic","year":"2006","journal-title":"Bone Marrow Transplant"},{"key":"R7-20240828","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.bbmt.2014.12.001","article-title":"National Institutes of Health Consensus Development Project on criteria for clinical trials in chronic graft-versus-host disease:I. 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