{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:44:13Z","timestamp":1787071453569,"version":"build-2736575974"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>This investigation aims to assess the clinical outcomes and patient-reported satisfaction associated with non-surgical eyebrow elevation utilizing botulinum toxin (BTX) and hyaluronic acid gel (HAG) formulations with G-prime fillers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on a cohort of 460 subjects who underwent eyebrow elevation procedures from 2013 to 2024. The sample comprised 276 females (60%) and 184 males (40%), with a mean age of 50 years (standard deviation [SD] = 31.1 years). In the BTX group, 20 units were administered across five injection sites, including bilateral injections into the corrugator supercilii and a unilateral injection into the procerus muscle, with 0.1 mL (4 units) per site using 31-gauge needles. Pre- and 15-day post-procedure photographic evaluations were analyzed using Adobe Photoshop, and statistical analysis was performed with Microsoft Excel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In the BTX cohort, the average increase in eyebrow height was 1.35 mm (range: 0.6\u20132.1 mm; SD = 1.06 mm), with a corresponding elevation from the medial limbus to the lateral brow edge averaging 1.35 mm (range: 1.0\u20131.7 mm; SD = 0.49 mm). The mean patient satisfaction score at 15 days post-treatment was similar for both groups: 1.73 for BTX and 1.71 for HAG, with no statistically significant difference observed (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.9540).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Both BTX and HAG G-prime fillers demonstrate considerable efficacy in non-surgical brow elevation, enhancing eyebrow contour, and restoring youthful facial aesthetics. These minimally invasive interventions are viable alternatives to surgical brow-lifting techniques, yielding comparable patient-reported outcomes and satisfaction levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2867_24","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T19:01:26Z","timestamp":1764010886000},"page":"1834-1839","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Eyebrow elevation using chemomodulation and myomodulation (Hyaluronic acid gel): A cohort analysis"],"prefix":"10.4103","volume":"73","author":[{"given":"Debraj","family":"Shome","sequence":"first","affiliation":[{"name":"Department of Facial Plastic Surgery and Facial Cosmetic Surgery, The Esthetic Clinics (TEC\u00ae), Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwin","family":"Prabhughate","sequence":"additional","affiliation":[{"name":"Department of Research, The Esthetic Clinics Clinical Research Organization (TECCRO), Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Depti","family":"Bellani","sequence":"additional","affiliation":[{"name":"Department of Medical Affairs, Esthetic Creations International Pvt Ltd. 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