{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:27:18Z","timestamp":1787758038468,"version":"build-2784847793"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>Brittle cornea syndrome (BCS) is a genetic connective tissue disorder with discernible ocular features such as blue scleral and thin cornea that predominantly presents in younger children. We herein describe cases of three siblings with BCS, two of whom presented to us with open globe injuries following trivial trauma. Clinical examination of the other eye in both showed diffusely thin corneas and blue sclera. A systemic evaluation revealed sensorineural hearing loss and hyperextensible joints. The third sibling was screened and found to have features concurrent with BCS. This report highlights the challenges faced in the management of ocular injuries and consecutive complications in these patients.<\/jats:p>","DOI":"10.4103\/ijo.ijo_2894_21","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T06:28:32Z","timestamp":1657607312000},"page":"2593-2597","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Brittle cornea syndrome: A tale of three brothers"],"prefix":"10.4103","volume":"70","author":[{"given":"Kunal","family":"Mandlik","sequence":"first","affiliation":[{"name":"Cornea and Refractive Services, Aravind Eye Hospital, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh A","family":"Betdur","sequence":"additional","affiliation":[{"name":"Cornea and Refractive Services, Aravind Eye Hospital, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Rashmita","sequence":"additional","affiliation":[{"name":"Cornea and Refractive Services, Aravind Eye Hospital, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivananda","family":"Narayana","sequence":"additional","affiliation":[{"name":"Cornea and Refractive Services, Aravind Eye Hospital, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"B1-20240828","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jaapos.2014.06.013","article-title":"Brittle cornea syndrome:A case report and comparison with Ehlers Danlos syndrome","volume":"18","author":"Ramappa","year":"2014","journal-title":"J AAPOS"},{"key":"B2-20240828","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.ajhg.2008.04.001","article-title":"Deleterious mutations in the zinc-finger 469 gene cause brittle cornea syndrome","volume":"82","author":"Abu","year":"2008","journal-title":"Am J Hum Genet"},{"key":"B3-20240828","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.2147\/OPTH.S185287","article-title":"Brittle cornea syndrome:Current perspectives","volume":"13","author":"Walkden","year":"2019","journal-title":"Clin Ophthalmol Auckl NZ"},{"key":"B4-20240828","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12886-018-0903-2","article-title":"Brittle cornea syndrome:A case report and review of the literature","volume":"18","author":"Wan","year":"2018","journal-title":"BMC Ophthalmol"},{"key":"B5-20240828","doi-asserted-by":"crossref","first-page":"5629","DOI":"10.1167\/iovs.14-14532","article-title":"Mutations in the zinc finger protein gene, ZNF469, contribute to the pathogenesis of keratoconus","volume":"55","author":"Vincent","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B6-20240828","first-page":"4381273","article-title":"Case series of brittle cornea syndrome","volume":"2020","author":"Eleiwa","year":"2020","journal-title":"Case Rep Ophthalmol Med"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ijo.IJO_2894_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:03:33Z","timestamp":1787756613000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ijo.IJO_2894_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,30]]},"references-count":6,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_2894_21","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,30]]},"assertion":[{"value":"2021-11-15","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-21","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}