{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:35:08Z","timestamp":1786649708561,"version":"build-2736575974"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>\n                      This case-control study aims to examine possible associations of\n                      <jats:italic toggle=\"yes\">VSX1<\/jats:italic>\n                      exon3 gene variants with the development of keratoconus (KC) in Malaysian patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A case-control study was done on 42 keratoconus cases, 127 family member controls, and 96 normal controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Three gene variants, p.A182A, p.P237P, and p.R217H showed significant associations with keratoconus (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). While p.A182A and p.P227P were more prevalent than in the family and normal controls (OR 3.14\u20134.05), the reverse was observed with p.R217H (OR 0.086\u20131.59). With Haploview analysis, p.A182A and p.P237P were shown to be in linkage disequilibrium (LD) (LOD (logarithm of the odds score) score of 2.0, r2 of 0.957, and 95% confidence interval (CI) of 0.96\u20131.00).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The study results suggest that the p.A182A and p.P237P variants could have contributed to the development of keratoconus in some Malaysians and that these two variants are likely to be co-inherited. In contrast, the p.R217H variant appeared to confer some protection against the development of keratoconus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2894_22","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T09:06:28Z","timestamp":1686733588000},"page":"2443-2447","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["The association between VSX1 exon3 gene variants and keratoconus in Malaysian patients"],"prefix":"10.4103","volume":"71","author":[{"given":"Jenny P","family":"Deva","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Sg Long, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun F","family":"Ngeow","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Sg Long, 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