{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T08:17:54Z","timestamp":1788164274058,"version":"build-2803163510"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To analyse the clinicopathological features, diagnostic pitfalls, and unusual presentations of eyelid eccrine tumors. Methods: Retrospective case series of 25 histopathologically confirmed eyelid eccrine tumors surgically excised between 2016 and 2023. Clinical records, histopathology (H&amp;E with selective PAS staining), and follow-up data were reviewed. Results: Eccrine hidrocystoma was the most common subtype (80%, n=20), followed by eccrine hidradenoma (16%, n=4) and eccrine spiradenoma (4%, n=1). Mean patient age was 43.8 years, with a 4:1 male predominance. Clinical misdiagnosis occurred in 84% of lesions, most commonly as sebaceous cysts (64%). cases demonstrated unusual features, including three giant hidrocystomas (&gt;2 cm), one giant hidradenoma (3.0 cm) with ulceration and mechanical ptosis clinically suspicious for squamous cell carcinoma, and one spiradenoma with maggot infestation mimicking malignancy. All giant tumors required excision with reconstruction (e.g., staged Cutler-Beard procedure). No recurrences were observed during follow-up (mean 14 months; range 6\u201324 months). Conclusion: Eyelid eccrine tumors present a broad clinical spectrum, from small cysts to large masses mimicking malignancy. Giant lesions, though rare, cause diagnostic confusion and functional impairment. Histopathological examination remains the gold standard for definitive diagnosis, and heightened clinical awareness is essential to avoid misdiagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2897_25","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T08:00:21Z","timestamp":1788163221000},"page":"1309-1312","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Giant and atypical eccrine tumors of the eyelid: A clinicopathologic analysis"],"prefix":"10.4103","volume":"74","author":[{"given":"Savita","family":"Agarwal","sequence":"first","affiliation":[{"name":"Department of Pathology, UPUMS, Etawah, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reena","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, UPUMS, Etawah, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beant","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Pathology, UPUMS, Etawah, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinki","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Pathology, UPUMS, Etawah, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surendra","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kalyan Singh Super Speciality Cancer Institute, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Gaur","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Pranil Health Care, Bulandshahar, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alka","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Pathology, UPUMS, Etawah, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"R1-20260831","first-page":"1835","article-title":"A retrospective study of 2228 cases with eyelid tumors","volume":"11","author":"Yu","year":"2018","journal-title":"Int J Ophthalmol"},{"key":"R2-20260831","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/sj.eye.6701404","article-title":"Eccrine hidrocystoma of the eyelid","volume":"19","author":"Singh","year":"2005","journal-title":"Eye (Lond)"},{"key":"R3-20260831","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/DAD.0b013e31821a4d33","article-title":"A study of histopathologic spectrum of nodular hidradenoma","volume":"34","author":"Nandeesh","year":"2012","journal-title":"Am J Dermatopathol"},{"key":"R4-20260831","first-page":"53","article-title":"Apocrine and eccrine hidrocystomas: A clinicopathological study","volume":"30","author":"Koumaki","year":"2021","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat"},{"key":"R5-20260831","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/DAD.0b013e3181961861","article-title":"Clinicopathological features of eyelid skin tumors. A retrospective study of 5504 cases and review of literature","volume":"31","author":"Deprez","year":"2009","journal-title":"Am J Dermatopathol"},{"key":"R6-20260831","doi-asserted-by":"crossref","first-page":"437","DOI":"10.5999\/aps.2014.41.4.437","article-title":"Giant eccrine hidradenoma mimicking a malignant tumor of the salivary gland","volume":"41","author":"Oh","year":"2014","journal-title":"Arch Plast Surg"},{"key":"R7-20260831","doi-asserted-by":"crossref","first-page":"S149","DOI":"10.1097\/IOP.0000000000001828","article-title":"Rapidly enlarging hidradenoma of the eyelid","volume":"37","author":"Hartford","year":"2021","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"R8-20260831","doi-asserted-by":"crossref","first-page":"e113","DOI":"10.5858\/2005-129-e113-CCHAMO","article-title":"Clear cell hidradenoma: A mimic of metastatic clear cell tumors","volume":"129","author":"Volmar","year":"2005","journal-title":"Arch Pathol Lab Med"},{"key":"R9-20260831","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1177\/1203475420915453","article-title":"Comparative efficacy of hidrocystoma treatments: A systematic review","volume":"24","author":"Trischman","year":"2020","journal-title":"J Cutan Med Surg"},{"key":"R10-20260831","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/01676830.2024.2317305","article-title":"Eccrine spiradenoma of eyelid - A rare tumor at an unusual location with literature review","volume":"44","author":"Pal","year":"2025","journal-title":"Orbit"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_2897_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T08:00:23Z","timestamp":1788163223000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_2897_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_2897_25","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]},"assertion":[{"value":"2025-11-13","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-18","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}