{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:30:16Z","timestamp":1787772616067,"version":"build-2784847793"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To study the retinal and choroidal thickness variations on enhanced depth imaging optical coherence tomography scans in ocular albinism (OA) and compare with age-matched healthy subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This retrospective observational study had 48 eyes of 24 patients diagnosed clinically as OA and age, sex, and axial length-matched control healthy subjects. All patients underwent detailed ophthalmic examination and a single-line horizontal-raster enhanced depth imaging \u2013 optical coherence tomography scan (Spectralis, Heidelberg Engineering). Retinal and choroidal thickness was measured, compared, and analyzed between the two groups. Mann\u2013Whitney U test was used for analysis between the two groups.\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05 was considered significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean age was 28.3 \u00b1 11.6 and 29.9 \u00b1 10.6 years in the OA group and control group, respectively. Spherical equivalents ranged from \u22128.5D to +10.5D in the OA group and from \u22128.0D to +10.0D in the control group. The mean axial length between the two groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.652) were comparable. The average retinal thickness (272 \u00b1 34.3 vs. 213 \u00b1 13.8 mm;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) was greater in the OA group as compared to controls. The mean choroidal thickness (184 \u00b1 78.4 vs. 287 \u00b1 46.4 mm;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) was significantly thinner in the OA group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Acquisition of OCT scans in OA can be challenging. This study showed that the subfoveal retinal thickness and choroidal thickness measured across the scans were significantly different in the OA group compared to controls. In the future, more studies are required to evaluate the role of the choroid and its relationship to emmetropization in albinism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2907_21","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T06:28:32Z","timestamp":1657607312000},"page":"2506-2510","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Choroidal and retinal thickness variations in ocular albinism"],"prefix":"10.4103","volume":"70","author":[{"given":"Ramesh","family":"Venkatesh","sequence":"first","affiliation":[{"name":"Department of Retina-Vitreous, Narayana Nethralaya, Benguluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameeksha","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Retina-Vitreous, Narayana Nethralaya, Benguluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikitha Gurram","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Retina-Vitreous, Narayana Nethralaya, Benguluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhila","family":"Sridharan","sequence":"additional","affiliation":[{"name":"Department of Retina-Vitreous, Narayana Nethralaya, Benguluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Ong","sequence":"additional","affiliation":[{"name":"Medical Retina and Vitreoretinal Surgery, University of Pittsburgh School of Medicine, Pittsburg, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naresh Kumar","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Retina-Vitreous, Narayana Nethralaya, Benguluru, Karnataka, 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