{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:23:06Z","timestamp":1787772186088,"version":"build-2784847793"},"reference-count":56,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>This study aims to investigate the relationship between pachychoroid spectrum disorders and retinitis pigmentosa (RP) or rod-cone dystrophy through a comprehensive literature review. The purpose is to explore the association between these disorders, understand their underlying mechanisms, and summarize the existing hypotheses and opinions. A thorough review of the literature was conducted using PubMed, focusing on articles related to central serous chorioretinopathy (CSC), RP, pachychoroid pigment epitheliopathy, pachychoroid neovasculopathy, polypoidal choroidal vasculopathy, focal choroidal excavation, peripapillary pachychoroid neovasculopathy, and peripheral exudative hemorrhagic chorioretinopathy. Relevant studies were selected for a detailed narrative review and analysis. Several studies have reported the coexistence of CSC and RP, indicating a potential association between the two conditions. The dysfunction of the retinal pigment epithelium is proposed as a common factor. Choroidal thinning is observed in RP, but conflicting results exist regarding choroidal thickness (CT). While some studies support choroidal thinning in RP, others suggest preserved or increased thickness. Additionally, cases of pachychoroid neovasculopathy and polypoidal choroidal vasculopathy in RP have been reported, suggesting an overlap between these conditions. The literature suggests conflicting reports on CT changes in RP. Future research should focus on large-scale studies using comprehensive imaging techniques, genetic analysis, and long-term follow-up to uncover the underlying mechanisms and determine the prevalence of pachychoroid spectrum disorders in RP patients.<\/jats:p>","DOI":"10.4103\/ijo.ijo_2909_23","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T02:00:11Z","timestamp":1713232811000},"page":"956-961","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Understanding the relationship between pachychoroid spectrum disorders and retinitis pigmentosa: A review of the evidence"],"prefix":"10.4103","volume":"72","author":[{"given":"Kasturi","family":"Chavan","sequence":"first","affiliation":[{"name":"Vitreoretina Services, Anant Bajaj Retina Institute, L V Prasad Eye Institute, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Chhablani","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhadra","family":"Jalali","sequence":"additional","affiliation":[{"name":"Vitreoretina Services, Anant Bajaj Retina Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srikanta Kumar","family":"Padhy","sequence":"additional","affiliation":[{"name":"Vitreoretina Services, Anant Bajaj Retina Institute, L V Prasad Eye Institute, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"key":"R1-20260506","first-page":"14","article-title":"Pachychoroid disease","volume":"33","author":"Cheung","year":"2019","journal-title":"Eye Lond Engl"},{"key":"R2-20260506","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/00007611-198001000-00026","article-title":"Coexisting central serous choroidopathy and retinitis pigmentosa","volume":"73","author":"Lewis","year":"1980","journal-title":"South Med J"},{"key":"R3-20260506","doi-asserted-by":"crossref","first-page":"55","DOI":"10.5693\/djo.02.2011.09.001","article-title":"Concurrence of retinitis pigmentosa and central serous retinopathy","volume":"17","author":"Rootman","year":"2011","journal-title":"Digit J Ophthalmol"},{"key":"R4-20260506","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/ICB.0000000000000225","article-title":"Recurrent central serous chorioretinopathy associated with retinitis pigmentosa treated with carbonic anhydrase inhibitors","volume":"10","author":"Pomykala","year":"2016","journal-title":"Retin Cases Brief Rep"},{"key":"R5-20260506","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/s00417-003-0819-1","article-title":"Central serous chorioretinopathy associated with retinitis pigmentosa","volume":"242","author":"Dorenboim","year":"2004","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"R6-20260506","doi-asserted-by":"crossref","first-page":"735.","DOI":"10.1016\/S0181-5512(08)74392-4","article-title":"[Retinitis pigmentosa and central serous choroiditis. 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