{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:28:11Z","timestamp":1786649291867,"version":"build-2736575974"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,6]]},"abstract":"\n Purpose:<\/jats:title>\n To analyze the pattern of bacterial pathogens causing infective keratitis and their resistance to the recommended antibiotics over six years.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n It was a retrospective study of 9,357 cases of bacterial keratitis from January 2015 to December 2020, at a tertiary care ophthalmic center. A total of 9,547 corneal specimens were obtained from the study subjects. Demographic details of the patients, pathogenic bacteria isolated, and their antimicrobial susceptibility were noted and analyzed.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Bacterial pathogens were identified in 23.52% of the specimens. The most common isolates were coagulase-negative\n Staphylococci<\/jats:italic>\n (60.75%), followed by\n Pseudomonas aeruginosa<\/jats:italic>\n (14.23%),\n Staphylococcus aureus<\/jats:italic>\n (13.92%), gram negative bacilli of the family\n Enterobacterales<\/jats:italic>\n (8.64%),\n Streptococcus<\/jats:italic>\n spp. (1.72%),\n Acinetobacter<\/jats:italic>\n spp. (0.13%), and other non-fermenting gram-negative bacilli (0.57%). In\n Staphylococci<\/jats:italic>\n , 55\u201380% of isolates were resistant to erythromycin, and 40\u201370% to fluoroquinolones, while no resistance was observed against vancomycin. 40\u201360% of isolates of\n P. aeruginosa<\/jats:italic>\n were resistant to cephalosporins, 40\u201355% to fluoroquinolones, and 30\u201360% to aminoglycosides. Also, 40\u201380% of isolates of\n Enterobacterales<\/jats:italic>\n were resistant to cephalosporins, and 50\u201360% to fluoroquinolones. Most gram-negative isolates were susceptible to carbapenems and polymyxin B.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n To the best of our knowledge, our study is the largest compilation of microbiological profile of bacterial keratitis from North India. It highlights the current trend of the bacterial pathogens that cause infectious keratitis.\n Staphylococci<\/jats:italic>\n and\n Pseudomonas<\/jats:italic>\n were found to be the most common pathogens. Increased resistance was seen against some of the commonly prescribed empirical antibiotics. Such evidence is useful for restructuring the empirical prescription practices from time to time.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2915_21","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T07:18:21Z","timestamp":1654067901000},"page":"1982-1989","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":20,"title":["Spectrum of bacterial keratitis in North India: A retrospective analysis of six years at a tertiary care eye center"],"prefix":"10.4103","volume":"70","author":[{"given":"Nishat H","family":"Ahmed","sequence":"first","affiliation":[{"name":"Ocular Microbiology, Dr R.P. Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepanshi","family":"Mishra","sequence":"additional","affiliation":[{"name":"Ocular Microbiology, Dr R.P. Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prachala","family":"Rathod","sequence":"additional","affiliation":[{"name":"Ocular Microbiology, Dr R.P. Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gita","family":"Satpathy","sequence":"additional","affiliation":[{"name":"Ocular Microbiology, Dr R.P. Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeewan S","family":"Titiyal","sequence":"additional","affiliation":[{"name":"Ophthalmology, Dr R.P. Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhika","family":"Tandon","sequence":"additional","affiliation":[{"name":"Ophthalmology, Dr R.P. Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushma","family":"Nandyala","sequence":"additional","affiliation":[{"name":"Ophthalmology, Dr R.P. Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tushar","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Ophthalmology, Dr R.P. Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murugesan","family":"Vanathi","sequence":"additional","affiliation":[{"name":"Ophthalmology, Dr R.P. Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Sinha","sequence":"additional","affiliation":[{"name":"Ophthalmology, Dr R.P. 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