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Compromise of corneal sensory nerves leads to neurotrophic keratopathy (NK), an uncommon degenerative disorder that may lead to corneal epithelial breakdown, ulceration, corneal opacification, and even perforation. Management of this condition is difficult and visual disability often ensues in affected patients. While treatment has been traditionally focused in promoting epithelial healing, the past decade has seen a breakthrough in new medical and surgical therapies geared toward promoting corneal reinnervation. This review presents a comprehensive update on NK, focusing on current as well as potential new strategies for its diagnosis and management.<\/jats:p>","DOI":"10.4103\/ijo.ijo_2963_24","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T08:57:38Z","timestamp":1743325058000},"page":"483-495","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Neurotrophic keratopathy: Update in diagnosis and management"],"prefix":"10.4103","volume":"73","author":[{"given":"Carlos Segundo","family":"Font","sequence":"first","affiliation":[{"name":"University of Illinois School of Medicine, Peoria, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Soledad","family":"Cortina","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois College of Medicine, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,3,27]]},"reference":[{"key":"R1-20260422","first-page":"13","article-title":"Corneal innervation and sensation: The eye and beyond","volume":"91","author":"Yang","year":"2018","journal-title":"Yale J Biol Med"},{"key":"R2-20260422","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.survophthal.2013.09.002","article-title":"Corneal nerves in health and disease","volume":"59","author":"Shaheen","year":"2014","journal-title":"Surv Ophthalmol"},{"key":"R3-20260422","first-page":"461","article-title":"Sensory and sympathetic innervation of the mammalian cornea. 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