{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:42:06Z","timestamp":1786725726754,"version":"build-2736575974"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To study the ophthalmologic manifestations of systemic sclerosis (SSc) and its correlation with autoantibody profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A cross-sectional study on 200 eyes of 100 consecutive adult patients diagnosed with SSc was performed at a tertiary care center in Northern India. The examination of ocular adnexa, anterior segment, and posterior segment with slit-lamp biomicroscopy, tear film break-up time (TBUT), Schirmer\u2019s II test, and choroidal thickness measurement by swept-source ocular coherence tomography was done. Autoantibody profile was available for 85 patients, and its statistical association with the ocular examination findings was analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In total, 100 patients (93 females and 7 males) were included. The mean age was 45.11 \u00b1 11.68 years, and the mean disease duration was 6.93 \u00b1 3.68 years. Meibomian gland disease was more commonly found in patients with the diffuse subtype of SSc (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.037). Choroidal thickness was increased in 34% and decreased in 7% (reference range = 307 \u00b1 79 \u00b5m) patients. Reduced TBUT, meibomian gland dysfunction, and eyelid stiffness had a statistically significant association with the presence of anti-Scl-70 antibody (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003, &lt;0.0001, and 0.004, respectively). These patients had ocular fatigue, foreign body sensation, and burning sensation. No significant association was noted with the presence of SS-A\/Ro and SS-B\/La antibodies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study highlights the need for an active comprehensive ophthalmic evaluation. Approximately 75% of the patients in our cohort had ocular involvement to varying extent. An isolated presence of anti-Scl70 antibody was also found to have a positive association with dry eye disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_2980_23","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T02:00:12Z","timestamp":1713232812000},"page":"1192-1198","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Ophthalmologic profile of patients with systemic sclerosis"],"prefix":"10.4103","volume":"72","author":[{"given":"Sandeep","family":"Choudhary","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Advanced Eye Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arghya","family":"Chattopadhyay","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Rheumatology Services, Postgraduate Institute of 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