{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:58:24Z","timestamp":1785437904307,"version":"3.56.0"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the effect of topical brinzolamide (Azopt) eye drops on nystagmus using videonystagmography in infants and children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Setting: Institutional (Cairo University Hospitals). Study population: Both eyes of 40 patients, presenting with nystagmus, with a maximal age of 14 years, were included in this prospective, nonrandomized, unmasked study. Intervention: Clinical evaluation and videonystagmography were carried out on entry, at 1 month, and 6 months of Azopt instillation and 1 month after its discontinuation. Azopt was stopped at 1 month in case of deterioration. Main outcome measures: The primary outcome of the study was the change in nystagmus intensity at 4 weeks of Azopt treatment, based on videonystagmography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Mean age was 5.7 \u00b1 3.3 years. There was a significant decrease in mean nystagmus amplitude from 8.39 \u00b1 7.67, on entry, to 5.95 \u00b1 5.31, 5.27 \u00b1 4.64, and 4.18 \u00b1 3.65 degrees at 1 month, 6 months, and 1 month after discontinuation (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). There was a significant decrease in slow phase velocity (SPV) from 29.53 \u00b1 22.19, on entry, to 20.43 \u00b1 18.62 degrees\/second at 6 months, and in nystagmus intensity from 1018.4 \u00b1 1530.9, on entry, to 319.3 \u00b1 322.05 at 6 months (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). Decrease in nystagmus frequency and visual improvement were insignificant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05). At 1 month, nystagmus intensity decreased in 62.5%, but increased in 32.5%. No side effects were documented.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Azopt eye drops significantly reduced nystagmus in infants and children, without side effects. Worsening of nystagmus was, however, noted in around one-third of the cases, so close follow-up is essential for timely discontinuation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_3000_25","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:00:20Z","timestamp":1785434420000},"page":"1201-1207","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the effect of brinzolamide 1% ophthalmic suspension on nystagmus using videonystagmography"],"prefix":"10.4103","volume":"74","author":[{"given":"Rehab Rashad","family":"Kassem","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Cairo University Hospitals, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein Sherif","family":"Hamdy","sequence":"additional","affiliation":[{"name":"Department of Audiology, Cairo University Hospitals, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina Hossameldin","family":"Hassanein","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Cairo University Hospitals, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randa Mohamed Abdel-Moneim","family":"El-Mofty","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Cairo University Hospitals, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"R1-20260730","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3368\/aoj.60.1.48","article-title":"Nystagmus in infancy and childhood: Characteristics and evidence for treatment","volume":"60","author":"Hertle","year":"2010","journal-title":"Am Orthop J"},{"key":"R2-20260730","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.pedneo.2014.02.007","article-title":"Nystagmus in 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Ophthalmol"}],"container-title":["Indian Journal of 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