{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T20:53:40Z","timestamp":1787864020547,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>Congenital corneal anesthesia (CCA) is an extremely rare condition where the cornea is affected in isolation or as a part of congenital syndrome, or can be associated with systemic anomalies. This case series of 12 eyes provides an overview of various clinical presentations and their final treatment outcomes. The average age of presentation was 3.2 years with a female preponderance (75%). Fifty percent of the patients had bilateral involvement and 50% had corneal ulcers at presentation. Two eyes required therapeutic keratoplasty for corneal perforation. All patients had isolated CCA except for one who had an associated hereditary and sensory autonomic neuropathy.<\/jats:p>","DOI":"10.4103\/ijo.ijo_3001_21","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T06:28:32Z","timestamp":1657607312000},"page":"2588-2591","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Congenital corneal anesthesia: A case series"],"prefix":"10.4103","volume":"70","author":[{"given":"Aruna P","family":"Jayarajan","sequence":"first","affiliation":[{"name":"Cornea and Refractive Services, Aravind Eye Hospital, Pondicherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dr.Ashok Sharma\u2019s Cornea Centre, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajan","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dr.Ashok Sharma\u2019s Cornea Centre, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verinder S","family":"Nirankari","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivananda","family":"Narayana","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dr.Ashok Sharma\u2019s Cornea Centre, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine S","family":"Christy","sequence":"additional","affiliation":[{"name":"Cornea and Refractive Services, Aravind Eye Hospital, Pondicherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"B1-20240828","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.survophthal.2006.10.004","article-title":"Congenital corneal anesthesia","volume":"52","author":"Ramaesh","year":"2007","journal-title":"Surv Ophthalmol"},{"key":"B2-20240828","doi-asserted-by":"crossref","first-page":"266","DOI":"10.4103\/ijo.IJO_2598_20","article-title":"Commentary:Congenital corneal anesthesia","volume":"69","author":"Kaur","year":"2021","journal-title":"Indian J Ophthalmol"},{"key":"B3-20240828","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1097\/00003226-200103000-00018","article-title":"Congenital corneal anesthesia:A series of four case reports","volume":"20","author":"Mathen","year":"2001","journal-title":"Cornea"},{"key":"B4-20240828","first-page":"1073","article-title":"Congenital trigeminal anaesthesia","volume":"107","author":"Rosenberg","year":"1984","journal-title":"A review and classification. 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