{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:34:44Z","timestamp":1786649684608,"version":"build-2736575974"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To understand the prognostic value of The Cancer Genome Atlas (TCGA) for uveal melanoma metastasis, using a simplified 4-category classification, based on tumor DNA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective cohort study of 1001 eyes with uveal melanoma at a single center, categorized according to TCGA as Group A, B, C, or D (by fine-needle aspiration biopsy for DNA analysis), and treated with standard methods, was studied for melanoma-related metastasis at 5 and 10 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of 1001 eyes with uveal melanoma, the TCGA categories included Group A (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 486, 49%), B (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 141, 14%), C (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 260, 26%), and D (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 114, 11%). By comparison, increasing category (A vs. B vs. C vs. D) was associated with features of older age at presentation (56.8 vs. 52.8 vs. 61.1 vs. 63.5 years,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), less often visual acuity of 20\/20\u201320\/50 (80% vs. 67% vs. 70% vs. 65%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001), tumor location further from the optic disc (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) and foveola (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), and greater median tumor basal diameter (10.0 vs. 13.0 vs. 14.0 vs. 16.0 mm,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) and tumor thickness (3.5 vs. 5.2 vs. 6.0 vs. 7.1 mm,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). The Kaplan\u2013Meier (5-year\/10-year) rate of metastasis was 4%\/6% for Group A, 12%\/20% for Group B, 33%\/49% for Group C, and 60%\/not available for Group D.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>A simplified 4-category classification of uveal melanoma using TCGA, based on tumor DNA, is highly predictive of risk for metastatic disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_313_21","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T14:43:02Z","timestamp":1624632182000},"page":"1839-1845","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":34,"title":["Ten-year outcomes of uveal melanoma based on The Cancer Genome Atlas (TCGA) classification in 1001 cases"],"prefix":"10.4103","volume":"69","author":[{"given":"Carol L","family":"Shields","sequence":"first","affiliation":[{"name":"Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen L","family":"Mayro","sequence":"additional","affiliation":[{"name":"Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"Bas","sequence":"additional","affiliation":[{"name":"Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip W","family":"Dockery","sequence":"additional","affiliation":[{"name":"Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Yaghy","sequence":"additional","affiliation":[{"name":"Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara E","family":"Lally","sequence":"additional","affiliation":[{"name":"Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arupa","family":"Ganguly","sequence":"additional","affiliation":[{"name":"Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry A","family":"Shields","sequence":"additional","affiliation":[{"name":"Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, 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