{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:19:48Z","timestamp":1787775588842,"version":"build-2784847793"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Optic nerve head drusen (ONHD), peripapillary hyperreflective ovoid mass-like structures (PHOMS), and horizontal hyperreflective lines (HHL) are commonly seen in eyes with pseudopapilledema on enhanced depth imaging (EDI) spectral domain optical coherence tomography (SDOCT). The objective of this study is to assess the frequency of ONHD, PHOMS, and HHL on spectral domain OCT in the eyes diagnosed to have pseudopapilledema.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective case\u2013control study included patients diagnosed as pseudopapilledema and had EDI SD OCT imaging of the optic nerve head (n = 48 eyes) and controls (n = 20 eyes). OCT scans through the optic nerve head were studied to diagnose ONHD, HHL, and PHOMS. One proportion z test was used to find the difference in proportions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Forty eight eyes of 27 subjects were studied. ONHD as described by the optic disc drusen Studies consortium was noted in 19 eyes (39.48%),\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value-0.032, PHOMS in 31 eyes (64.6%),\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value 0.043, HL in 19 eyes (39.48%),\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value 0.032, and none of the normals had ONHD, PHOMS, and HHL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>PHOMS are more frequently seen than ONHD and HHL in eyes with pseudopapilledema.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_3146_22","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T11:18:47Z","timestamp":1697800727000},"page":"3552-3557","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Understanding pseudopapilledema on spectral domain optical coherence tomography"],"prefix":"10.4103","volume":"71","author":[{"given":"Shikha Talwar","family":"Bassi","sequence":"first","affiliation":[{"name":"Neuroophthalmology Services, Sankara Nethralaya, 18 College Road, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Pamu","sequence":"additional","affiliation":[{"name":"Comprehensive Ophthalmology, Neuroophthalmology Services, Sankara Nethralaya, 18 College Road, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjaly","family":"Varghese","sequence":"additional","affiliation":[{"name":"Department of Optometry, Sankara Nethralaya, 18 College Road, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,10,20]]},"reference":[{"key":"R1-20260511","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1001\/jama.1962.03050290013003","article-title":"Pseudopapilledema: Anomalous elevation of optic disk: Pitfalls in diagnosis and management","volume":"181","author":"Hoyt","year":"1962","journal-title":"JAMA"},{"key":"R2-20260511","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.survophthal.2016.03.007","article-title":"Optic disk drusen in children","volume":"61","author":"Chang","year":"2016","journal-title":"Surv Ophthalmol"},{"key":"R3-20260511","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/IJG.0b013e31818624a4","article-title":"Imaging of optic nerve head drusen: Improvements with spectral domain optical coherence tomography","volume":"18","author":"Yi","year":"2009","journal-title":"J Glaucoma"},{"key":"R4-20260511","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/WNO.0000000000000585","article-title":"The Optic disc drusen studies consortium recommendations for diagnosis of optic disc drusen using optical coherence tomography","volume":"38","author":"Malmqvist","year":"2018","journal-title":"J Neuroophthalmol"},{"key":"R5-20260511","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/s41433-020-1067-x","article-title":"Peripapillary hyperreflective ovoid mass-like structures-a novel entity as frequent cause of pseudopapilledema in children","volume":"35","author":"Mezad-Koursh","year":"2021","journal-title":"Eye (Lond)"},{"key":"R6-20260511","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s00417-012-2223-1","article-title":"Sensitivity and specificity of monochromatic photography of the ocular fundus in differentiating optic nerve head drusen and optic disc oedema","volume":"251","author":"Gili","year":"2013","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"R7-20260511","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2214\/ajr.162.1.8273656","article-title":"Sonography in optic disk drusen: Imaging findings and role in diagnosis when funduscopic findings are normal","volume":"162","author":"McNicholas","year":"1994","journal-title":"Am J Roentgenol"},{"key":"R8-20260511","first-page":"85","article-title":"Echographic evaluation of optic disc drusen","volume":"11","author":"Boldt","year":"1991","journal-title":"J Clin Neuroophthalmol"},{"key":"R9-20260511","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1038\/eye.2014.210","article-title":"The role of orbital ultrasonography in distinguishing papilledema from pseudopapilledema","volume":"28","author":"Carter","year":"2014","journal-title":"Eye (Lond)"},{"key":"R10-20260511","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1001\/archopht.117.8.1045","article-title":"A comparison of imaging techniques for diagnosing drusen of the optic nerve head","volume":"117","author":"Kurz-Levin","year":"1999","journal-title":"Arch Ophthalmol (Chicago, Ill 1960)"},{"key":"R11-20260511","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s10792-014-9939-3","article-title":"Optic nerve head drusen: A comparative study of 10 MHz and 20 MHz ultrasound probes","volume":"35","author":"Zaouali","year":"2015","journal-title":"Int Ophthalmol"},{"key":"R12-20260511","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jaapos.2015.02.014","article-title":"The cost-effectiveness of different strategies to evaluate optic disk drusen in children","volume":"19","author":"Moosajee","year":"2015","journal-title":"J Am Assoc Pediatr Ophthalmol Strabismus"},{"key":"R13-20260511","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1755-3768.1982.tb00616.x","article-title":"Optic disc drusen--a photographic study. I. Autofluorescence pictures and fluorescein angiography","volume":"60","author":"Mustonen","year":"1982","journal-title":"Acta Ophthalmol"},{"key":"R14-20260511","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/WNO.0000000000000654","article-title":"The influence of volume and anatomic location of optic disc drusen on the sensitivity of autofluorescence","volume":"39","author":"Loft","year":"2019","journal-title":"J Neuroophthalmol"},{"key":"R15-20260511","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/WNO.0b013e31823010b8","article-title":"Fluorescein angiographic identification of optic disc drusen with and without optic disc edema","volume":"32","author":"Pineles","year":"2012","journal-title":"J Neuroophthalmol"},{"key":"R16-20260511","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3109\/01658100903360338","article-title":"Fundus autofluorescence in optic disc drusen: Comparison of confocal scanning laser ophthalmoscope and standard fundus camera","volume":"33","author":"Asli Dinc","year":"2009","journal-title":"Neuro-Ophthalmology"},{"key":"R17-20260511","first-page":"359","article-title":"Heidelberg retina tomography analysis in optic disks with anatomic particularities","volume":"3","author":"Dascalu","year":"2010","journal-title":"J Med Life"},{"key":"R18-20260511","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.ajo.2013.01.024","article-title":"Morphologic characteristics of optic nerve head drusen on spectral-domain optical coherence tomography","volume":"155","author":"Lee","year":"2013","journal-title":"Am J Ophthalmol"},{"key":"R19-20260511","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/aos.13748","article-title":"Optic disc drusen: Understanding an old problem from a new perspective","volume":"96","author":"Hamann","year":"2018","journal-title":"Acta Ophthalmol"},{"key":"R20-20260511","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.ophtha.2012.12.035","article-title":"Enhanced depth imaging optical coherence tomography of optic nerve head drusen","volume":"120","author":"Merchant","year":"2013","journal-title":"Ophthalmology"},{"key":"R21-20260511","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1097\/WNO.0000000000001248","article-title":"Utility of ultrasound and optical coherence tomography in differentiating between papilledema and pseudopapilledema in children","volume":"41","author":"Farazdaghi","year":"2021","journal-title":"J Neuroophthalmol"},{"key":"R22-20260511","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/01658107.2020.1810286","article-title":"Diagnosing optic disc drusen in the modern imaging era: A practical approach","volume":"45","author":"Costello","year":"2020","journal-title":"Neuroophthalmology"},{"key":"R23-20260511","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/aos.14180","article-title":"Prevalence and histopathological signatures of optic disc drusen based on microscopy of 1713 enucleated eyes","volume":"98","author":"Skougaard","year":"2020","journal-title":"Acta Ophthalmol"},{"key":"R24-20260511","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1136\/bjo.59.8.413","article-title":"Drusen of the optic disc. A retrospective study in cadaver eyes","volume":"59","author":"Friedman","year":"1975","journal-title":"Br J Ophthalmol"},{"key":"R25-20260511","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3928\/15428877-20091230-15","article-title":"Characteristics of optic nerve head drusen on optical coherence tomography images","volume":"41","author":"Wester","year":"2010","journal-title":"Ophthalmic Surg Lasers Imaging"},{"key":"R26-20260511","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1167\/iovs.17-21608","article-title":"Quantitatively measured anatomic location and volume of optic disc drusen: An enhanced depth imaging optical coherence tomography study","volume":"58","author":"Malmqvist","year":"2017","journal-title":"Invest Opthalmol Vis Sci"},{"key":"R27-20260511","first-page":"298","article-title":"Dr\u00fazy papily zrakov\u00e9ho nervu a jejich komplikace [Optic Disc Drusen and their Complications]","volume":"72","author":"\u0160trofov\u00e1","year":"2016","journal-title":"Cesk Slov Oftalmol"},{"key":"R28-20260511","first-page":"19","article-title":"Planimetric optic disc parameters in normal eyes: A population-based study in South India","volume":"49","author":"Sekhar","year":"2001","journal-title":"Indian J Ophthalmol"},{"key":"R29-20260511","doi-asserted-by":"crossref","first-page":"99","DOI":"10.4103\/0301-4738.39112","article-title":"Optic disc topography of normal Indian eyes: An assessment using optical coherence tomography","volume":"56","author":"Dacosta","year":"2008","journal-title":"Indian J Ophthalmol"},{"key":"R30-20260511","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/opo.12017","article-title":"Comparison of optic area measurement using fundus photography and optical coherence tomography between optic nerve head drusen and control subjects","volume":"33","author":"Flores-Rodr\u00edguez","year":"2013","journal-title":"Ophthalmic Physiol Opt"},{"key":"R31-20260511","first-page":"4885","article-title":"Optic disc drusen: Prevalence, ocular and systemic associations in the Gutenberg Health Study","volume":"53","author":"Hoehn","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R32-20260511","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.4103\/0301-4738.149136","article-title":"Optical coherence tomography in papilledema and pseudopapilledema with and without optic nerve head drusen","volume":"62","author":"Bassi","year":"2014","journal-title":"Indian J Ophthalmol"},{"key":"R33-20260511","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1001\/archophthalmol.2008.524","article-title":"Differentiating optic disc edema from optic nerve head drusen on optical coherence tomography","volume":"127","author":"Johnson","year":"2009","journal-title":"Arch Ophthalmol"},{"key":"R34-20260511","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1007\/s00417-014-2773-5","article-title":"Measurement of retinal nerve fiber layer and macular ganglion cell\u2013inner plexiform layer with spectral-domain optical coherence tomography in patients with optic nerve head drusen","volume":"252","author":"Casado","year":"2014","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"R35-20260511","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/WNO.0000000000000641","article-title":"Optic nerve head and macular optical coherence tomography measurements in papilledema compared with pseudopapilledema","volume":"39","author":"Aghsaei Fard","year":"2019","journal-title":"J Neuroophthalmol"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_3146_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:33:49Z","timestamp":1787772829000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_3146_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,20]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_3146_22","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,20]]},"assertion":[{"value":"2022-12-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-17","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}