{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:27:08Z","timestamp":1787776028161,"version":"build-2784847793"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To compare posterior corneal morphology between older treated and younger untreated children with primary congenital glaucoma (PCG) using anterior segment optical coherence tomography (ASOCT) and intraoperative OCT (iOCT), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this comparative study, ASOCT of older PCG children were compared with iOCT of younger untreated PCG patients. Differences between the two groups with respect to posterior corneal morphology were studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Observed morphological patterns within posterior cornea in older treated (age: 72\u2013300 months) children (87 eyes) included Descemet\u2019s membrane (DM) excrescences (70%), thickened DM (35%), intracameral twin protuberances (92%), and DM detachment (26%). Changes within pre-Descemet\u2019s layer (PDL) (28%) included thickening, breaks, and detachments. Extent of Haab\u2019s striae was associated with thickness of DM\/PDL complex (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.008) when analyzed in the treated group. In contrast, in the untreated group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 53 eyes, age 1\u201363 months), posterior corneal changes were limited to diffuse hyper-reflectivity of the DM\/PDL complex, with absence of DM tears.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Posterior cornea thickens and Haab\u2019s striae become more circumscribed in eyes of older treated children compared to untreated PCG eyes, probably reflecting a healing response of posterior cornea over time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_317_22","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T06:28:32Z","timestamp":1657607312000},"page":"2571-2577","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Posterior corneal morphological changes in primary congenital glaucoma"],"prefix":"10.4103","volume":"70","author":[{"given":"Shikha","family":"Gupta","sequence":"first","affiliation":[{"name":"Glaucoma Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthikeyan","family":"Mahalingam","sequence":"additional","affiliation":[{"name":"Glaucoma Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Singh","sequence":"additional","affiliation":[{"name":"Glaucoma Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harathy","family":"Selvan","sequence":"additional","affiliation":[{"name":"Glaucoma Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bindu I","family":"Somarajan","sequence":"additional","affiliation":[{"name":"Glaucoma Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viney","family":"Gupta","sequence":"additional","affiliation":[{"name":"Glaucoma Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"B1-20240828","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3109\/02713689609017610","article-title":"The composition of wide-spaced collagen in normal and diseased Descemet's membrane","volume":"15","author":"Levy","year":"1996","journal-title":"Curr Eye Res"},{"key":"B2-20240828","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.ajo.2014.01.017","article-title":"Acute corneal hydrops in keratoconus-new perspectives","volume":"157","author":"Fan Gaskin","year":"2014","journal-title":"Am J Ophthalmol"},{"key":"B3-20240828","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1097\/ICO.0b013e318172fbff","article-title":"Optical coherence tomography and in vivo confocal microscopy features of obstetric injury of the cornea","volume":"27","author":"Szaflik","year":"2008","journal-title":"Cornea"},{"key":"B4-20240828","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1444-0938.2010.00519.x","article-title":"Imaging inadvertent Descemet's membrane break secondary to cataract surgery","volume":"94","author":"Yang","year":"2011","journal-title":"Clin Exp Optom"},{"key":"B5-20240828","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S0161-6420(82)34747-8","article-title":"The differential diagnosis of Descemet's tears (Haab's striae) and posterior polymorpous dystrophy bands. 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