{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:36:24Z","timestamp":1786628184280,"version":"build-2736575974"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>\n                      Ocular infections caused by\n                      <jats:italic toggle=\"yes\">Trichosporon<\/jats:italic>\n                      spp., a yeast-like fungus and an emerging fungal pathogen associated with severe invasive disease and poor outcomes, remain underexplored, with only a few case reports available. We present a decade-long case series of\n                      <jats:italic toggle=\"yes\">Trichosporon<\/jats:italic>\n                      ocular infections, describing clinical features, detailed microbiology, clinico-microbiological correlations, antifungal susceptibility patterns, and genotyping of isolates. A comprehensive literature review of all reported cases to date is also included.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A retrospective review of electronic medical records (EMRs) identified eight cases of\n                      <jats:italic toggle=\"yes\">Trichosporon<\/jats:italic>\n                      ocular infections over a 12-year period. Demographic, clinical, and microbiological data were extracted from EMRs. Five stored isolates were retrieved from \u221280\u00b0C stocks for genotyping by Sanger sequencing and\n                      <jats:italic toggle=\"yes\">in-vitro<\/jats:italic>\n                      antifungal susceptibility testing. Relevant statistical analyses were performed to assess clinico-microbiological correlations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Fifty percent of patients had favorable clinical outcomes.\n                      <jats:italic toggle=\"yes\">Trichosporon asahii<\/jats:italic>\n                      was the most common species isolated and was associated with poorer outcomes compared to\n                      <jats:italic toggle=\"yes\">T. inkin<\/jats:italic>\n                      . Multidrug resistance (MDR) was frequent and correlated with worse prognosis. Natamycin was the most frequently administered antifungal agent, followed by azoles. Microbiological confirmation guided initiation of antifungal therapy in half of the cases. Sanger sequencing corrected species misidentifications made by the Vitek2 Compact system.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Trichosporon<\/jats:italic>\n                      ocular infections remain rare but can affect both immunocompromised and immunocompetent individuals. Poor outcomes were associated with MDR strains and pre-existing ocular conditions. Azoles demonstrated better therapeutic responses compared to other antifungal agents.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_3192_25","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T09:00:13Z","timestamp":1785747613000},"page":"S221-S231","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Trichosporon ocular infections: Genotyping, antifungal susceptibility, clinico-microbiological correlation, and literature review"],"prefix":"10.4103","volume":"74","author":[{"given":"Sanchita","family":"Mitra","sequence":"first","affiliation":[{"name":"Ocular Microbiology, Jhaveri Microbiology Centre and Prof. Brien Holden Eye Research Centre, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, Telangana, India"},{"name":"Medical Microbiology, Central Laboratory, Mamata Academy of Medical Sciences, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somasheila","family":"Murthy","sequence":"additional","affiliation":[{"name":"Cornea and Anterior Segment, Shantilal Sanghvi Cornea Institute, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, Telangana, India"},{"name":"Cornea and Anterior Segment Services, Shantilal Shanghvi Eye Institute, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"R1-20260813","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-1-4939-6515-1_2","article-title":"The Changing Epidemiology of Invasive Fungal Infections","volume":"1508","author":"Enoch","year":"2017","journal-title":"Methods Mol Biol."},{"key":"R2-20260813","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3390\/jof5030067","article-title":"Emerging fungal infections: New patients, new patterns, and new pathogens","volume":"5","author":"Friedman","year":"2019","journal-title":"J Fungi (Basel)"},{"key":"R3-20260813","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/s41433-019-0358-6","article-title":"Invasive sino-orbital fungal infections in immunocompetent patients: A clinico-pathological study","volume":"33","author":"Adulkar","year":"2019","journal-title":"Eye (Lond)"},{"key":"R4-20260813","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.mmcr.2018.10.006","article-title":"Invasive fungal infection by Aspergillus flavus in immunocompetent hosts: A case series and literature review","volume":"23","author":"Garcia-Giraldo","year":"2018","journal-title":"Med Mycol Case Rep"},{"key":"R5-20260813","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jgar.2017.10.024","article-title":"Does the use of antifungal agents in agriculture and food foster polyene resistance development? 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