{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:42:28Z","timestamp":1786725748078,"version":"build-2736575974"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,8]]},"abstract":"\n Purpose:<\/jats:title>\n It was aimed to compare corneal endothelial changes during the initial 12-month period in which patients started using atorvastatin after a diagnosis of acute coronary syndrome (ACS).<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n Forty-six participants (group 1) who underwent cardiac angioplasty and stenting for ACS and started using 80 mg atorvastatin in the early period were included in the study. In the study, a control group comprising 71 healthy adults (group 2) was included. These individuals did not use medication for any known systemic disease, had never taken statins, had no history of ocular surgery, and did not have any cornea-related eye diseases. Baseline and 12\n th<\/jats:sup>\n month endothelial evaluations of group 1 and 2 participants were compared using specular microscopy.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n There were 28 female and 18 male participants in group 1 and 48 female and 23 male participants in group 2 (\n P<\/jats:italic>\n = 0.455). The mean baseline corneal endothelial cell density (CECD) was not significantly higher in group 1 compared to group 2 (2471.4 \u00b1 200 cells\/mm\n 2<\/jats:sup>\n vs 2428.2 \u00b1 539.8 cells\/mm\n 2<\/jats:sup>\n ,\n P<\/jats:italic>\n = 0.230). When the change between baseline and 12\n th<\/jats:sup>\n month CECD was examined, the decrease in group 2 was significantly different from that in group 1 (-15,2 \u00b1 31,9 and -44,8 \u00b1 49,6,\n P<\/jats:italic>\n = 0,002). Although the percentage of hexagonal cells decreased significantly in group 2 participants, no significant change was observed in group 1 (respectively;\n P<\/jats:italic>\n < 0.001,\n P<\/jats:italic>\n = 0.073). The endothelial cell coefficient of variation did not differ significantly in group 1 participants over a 1-year period (\n P<\/jats:italic>\n = 0.192), and a significant increase was observed in group 2 (\n P<\/jats:italic>\n < 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n This study revealed that atorvastatin may have a positive effect on corneal endothelium cell density and morphology.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijo.ijo_3201_23","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T08:09:33Z","timestamp":1722240573000},"page":"1142-1146","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the effect of atorvastatin on corneal endothelial cells during the initial 12-month period after acute coronary syndrome"],"prefix":"10.4103","volume":"72","author":[{"given":"Murat","family":"Karapapak","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130rem","family":"Demirtola","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve","family":"Kelebek","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ece","family":"Ozal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serhat","family":"Ermis","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadik","family":"Ozal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"key":"R1-20260507","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/0014-4835(76)90003-8","article-title":"Changes in the corneal endothelium as a function of age","volume":"22","author":"Laing","year":"1976","journal-title":"Exp Eye Res"},{"key":"R2-20260507","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1136\/bjo.68.8.544","article-title":"Morphological change in the corneal endothelium due to ultraviolet radiation in welders","volume":"68","author":"Karai","year":"1984","journal-title":"Br J Ophthalmol"},{"key":"R3-20260507","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0002-9394(82)90693-6","article-title":"Clinical \u0131nvestigations on the corneal endothelium","volume":"93","author":"Mishima","year":"1982","journal-title":"Am J Ophthalmol"},{"key":"R4-20260507","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.survophthal.2019.01.013","article-title":"Statins in ophthalmology","volume":"64","author":"Ooi","year":"2019","journal-title":"Surv Ophthalmol"},{"key":"R5-20260507","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2174\/1389450023347434","article-title":"HMG-Co A reductase \u0131nhibitors in the treatment of cardiovascular diseases: Stabilization of coronary artery plaque","volume":"3","author":"Morishita","year":"2002","journal-title":"Curr Drug Targets"},{"key":"R6-20260507","doi-asserted-by":"crossref","first-page":"282","DOI":"10.2174\/187152707781387260","article-title":"Therapeutic potential of 3-hydroxy-3-methylglutaryl coenzyme a reductase \u0131nhibitors for the treatment of retinal and eye diseases","volume":"6","author":"Schmeer","year":"2007","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"R7-20260507","first-page":"237.","article-title":"Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes. 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