{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:58:16Z","timestamp":1785437896711,"version":"3.56.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>The study aimed to compare retinal nerve fiber layer (RNFL) and optic disc measurements obtained using three optical coherence tomography (OCT) devices\u2014Heidelberg Spectralis, Zeiss Cirrus 5000, and Optovue Solix Essential\u2014in healthy individuals, and to assess interdevice agreement and clinical applicability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This prospective study involved 70 healthy participants. RNFL thickness (mean, superior, inferior, nasal, and temporal) and optic disc parameters (rim area, disc area, and vertical cup-to-disc ratio) were measured on the same day using the three OCT devices. Scans with poor quality or segmentation errors were excluded. Statistical comparisons were made using the Friedman and Wilcoxon tests, while interdevice agreement was evaluated using intraclass correlation coefficients (ICCs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Significant differences in RNFL thickness were found between devices in all segments (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). The highest RNFL thickness was observed with the Heidelberg device in the superior segment (Median: 128 \u00b5m), while the lowest was recorded with Optovue (median: 115.5 \u00b5m). Optic disc parameters, including rim area and disc area, were larger with the Optovue device, whereas the vertical cup-to-disc ratio was greater with the Zeiss device. Despite significant differences, ICC analyses indicated high interdevice agreement for RNFL (ICC = 0.97) and optic disc parameters (ICC = 0.90).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although RNFL and optic disc values differed among devices, the strong interdevice agreement indicates that OCT data remain clinically interpretable across platforms. With appropriate awareness of device-specific variability, these measurements appear reliable for patient monitoring and research, though studies in clinical cohorts are needed to clarify their relevance to optic nerve disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_3235_25","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:00:18Z","timestamp":1785434418000},"page":"1208-1213","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparative analysis of RNFL and optic disc measurements across three OCT devices in healthy eyes: Implications for device standardization and clinical practice"],"prefix":"10.4103","volume":"74","author":[{"given":"Eyupcan","family":"Sensoy","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Ankara Etlik City Hospital, University of Health Sciences, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Citirik","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ankara Etlik City Hospital, University of Health Sciences, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammet E","family":"Ery\u0131lmaz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ankara Etlik City Hospital, University of Health Sciences, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"R1-20260730","first-page":"1178","article-title":"Optical coherence tomography","volume":"254","author":"Huang","year":"1991","journal-title":"Science (1979)"},{"key":"R2-20260730","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/00055735-199504000-00014","article-title":"Optical coherence tomography: A new tool for glaucoma diagnosis","volume":"6","author":"Schuman","year":"1995","journal-title":"Curr Opin Ophthalmol"},{"key":"R3-20260730","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1001\/archopht.123.4.464","article-title":"Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma","volume":"123","author":"Wollstein","year":"2005","journal-title":"Arch Ophthalmol"},{"key":"R4-20260730","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1038\/eye.2008.258","article-title":"Effects of scan circle displacement in optical coherence tomography retinal nerve fibre layer thickness measurement: A RNFL modelling study","volume":"23","author":"Cheung","year":"2009","journal-title":"Eye (Lond)"},{"key":"R5-20260730","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1167\/iovs.07-0873","article-title":"Optical coherence tomography scan circle location and mean retinal nerve fiber layer measurement variability","volume":"49","author":"Gabriele","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R6-20260730","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/978-3-030-16638-0_3","article-title":"Optical coherence tomography (OCT): Principle and technical realization","author":"Aumann","year":"2019","journal-title":"High Resolution Imaging in Microscopy and Ophthalmology"},{"key":"R8-20260730","article-title":"SPECTRALIS OCT-The ophthalmic Imaging Platform | Heidelberg Engineering"},{"key":"R9-20260730","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1159\/000442770","article-title":"Optical coherence tomography angiography using the optovue device","volume":"56","author":"Huang","year":"2016","journal-title":"Dev Ophthalmol"},{"key":"R10-20260730","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.ajo.2010.06.024","article-title":"Comparison of retinal nerve fiber layer thickness in normal eyes using time-domain and spectral-domain optical coherence tomography","volume":"150","author":"Seibold","year":"2010","journal-title":"Am J Ophthalmol"},{"key":"R11-20260730","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1136\/bjo.2009.166314","article-title":"Comparison of retinal nerve fibre layer thickness measurements calculated by the optic nerve head map (NHM4) and RNFL3.45 modes of spectral-domain optical coherence tomography (RTVue-100)","volume":"94","author":"Shin","year":"2010","journal-title":"Br J Ophthalmol"},{"key":"R12-20260730","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1167\/iovs.04-1000","article-title":"Comparability of retinal nerve fiber layer thickness measurements of optical coherence tomography instruments","volume":"46","author":"Bourne","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R13-20260730","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1097\/IJG.0b013e318193c29f","article-title":"Comparison of retinal nerve fiber layer thickness values using stratus optical coherence tomography and Heidelberg retina tomograph-III","volume":"18","author":"Moreno-Monta\u00f1\u00e9s","year":"2009","journal-title":"J Glaucoma"},{"key":"R14-20260730","doi-asserted-by":"crossref","first-page":"5912","DOI":"10.1167\/iovs.11-8644","article-title":"Retinal nerve fiber layer thickness reproducibility using seven different OCT \u0131nstruments","volume":"53","author":"Pierro","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R15-20260730","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/IJG.0b013e3181d786f8","article-title":"Macular and retinal nerve fiber layer thickness measurements in normal eyes with the stratus OCT, the cirrus HD-OCT, and the topcon 3D OCT-1000","volume":"20","author":"Huang","year":"2011","journal-title":"J Glaucoma"},{"key":"R16-20260730","doi-asserted-by":"crossref","first-page":"5386","DOI":"10.1167\/iovs.07-1435","article-title":"Reproducibility of nerve fiber layer thickness measurements using 3D Fourier-domain OCT","volume":"49","author":"Menke","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R17-20260730","doi-asserted-by":"crossref","first-page":"4258","DOI":"10.3390\/jcm14124258","article-title":"Establishment of normative retinal nerve fiber layer thickness in healthy Koreans using Huvitz optical coherence tomography and comparison with cirrus OCT","volume":"14","author":"Kim","year":"2025","journal-title":"J Clin Med"},{"key":"R18-20260730","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ajo.2008.08.008","article-title":"Inter-device variability of the stratus optical coherence tomography","volume":"147","author":"Barkana","year":"2009","journal-title":"Am J Ophthalmol"},{"key":"R19-20260730","doi-asserted-by":"crossref","first-page":"1612455","DOI":"10.3389\/fcell.2025.1612455","article-title":"Standardized conversion model for retinal thickness measurements between spectral-domain and swept-source optical coherence tomography based on machine learning","volume":"13","author":"Tian","year":"2025","journal-title":"Front Cell Dev Biol"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_3235_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:00:44Z","timestamp":1785434444000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_3235_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_3235_25","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,31]]},"assertion":[{"value":"2025-12-17","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-19","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}