{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:23:10Z","timestamp":1787775790749,"version":"build-2784847793"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,3]]},"abstract":"\n Purpose:<\/jats:title>\n The purpose of this study is to present the clinico-demographic characteristics of pseudophakic bullous keratopathy (PBK), its visual outcomes, factors associated with the choice of treatment, and poor visual outcomes of PBK.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n In this hospital-based retrospective study, electronic medical records data of new patients who presented to a multi-tier ophthalmology hospital network in India (November 2010\u2013June 2022) were extracted. Patients with at least 4 weeks of follow-up were analyzed for visual outcome data. Bivariate analysis and multivariate logistic regression were used to determine the factors associated with the treatment choice and poor visual outcomes.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Of the 3,323,247 electronic records (with an average follow-up of 293 days) examined, 10,522 eyes of 10,158 patients (0.3%) had PBK. The majority were managed non-surgically (\n n<\/jats:italic>\n = 7372; 70.1%), with increased odds of poor visual outcome by 3.46 times (AdjOR: 3.04\u20133.92,\n P<\/jats:italic>\n < 0.001). Those belonging to the non-paying category had higher odds of poor visual outcome (AdjOR: 1.48, 95%CI: 1.29\u20131.69;\n P<\/jats:italic>\n < 0.001). Surgical management improved vision by 0.72 logMAR (95%CI: 0.60\u20130.73;\n P<\/jats:italic>\n < 0.001). A total of 41.2% (\n n<\/jats:italic>\n = 113\/274) of cases that underwent Descemet\u2019s membrane endothelial keratoplasty and 18.4% (\n n<\/jats:italic>\n = 285\/1551) of Descemet\u2019s stripping endothelial keratoplasty attained last follow-up visual acuity (LVA) of 6\/18 or better.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n About three in every thousand patients had PBK. Surgical interventions improved visual acuity significantly. About four in ten patients who underwent DMEK attained a vision of 6\/18 or better at the last follow-up visit. Markers of lower socioeconomic strata were independently associated with poor visual outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijo.ijo_323_24","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T08:01:14Z","timestamp":1726732874000},"page":"363-369","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Clinico-demographic profile and visual outcomes of pseudophakic bullous keratopathy in a multi-tier eyecare network in India"],"prefix":"10.4103","volume":"73","author":[{"given":"Anthony Vipin","family":"Das","sequence":"first","affiliation":[{"name":"Department of Eye Smart EMR and A Eye, L V Prasad Eye Institute, Hyderabad, Telangana, India"},{"name":"Indian Health Outcomes, Public Health and Economics Research Center, L V Prasad Eye Institute, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soujanya","family":"Kaup","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Yenepoya Medical College and Hospital, Deralakatte, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujata","family":"Das","sequence":"additional","affiliation":[{"name":"Cornea and Anterior Segment Service, L V Prasad Eye Institute, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,9,19]]},"reference":[{"key":"R1-20260422","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.exer.2011.08.014","article-title":"Proliferative capacity of corneal endothelial cells","volume":"95","author":"Joyce","year":"2012","journal-title":"Exp Eye Res"},{"key":"R2-20260422","first-page":"779","article-title":"Central corneal endothelial cell changes over a ten-year period","volume":"38","author":"Bourne","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R3-20260422","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/S0161-6420(94)31224-3","article-title":"Continued endothelial cell loss ten years after lens implantation","volume":"101","author":"Bourne","year":"1994","journal-title":"Ophthalmology"},{"key":"R4-20260422","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.jcrs.2012.11.026","article-title":"Visual outcome of cataract surgery; study from the European Registry of Quality Outcomes for Cataract and Refractive Surgery","volume":"39","author":"Lundstr\u00f6m","year":"2013","journal-title":"J Cataract Refract Surg"},{"key":"R5-20260422","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1136\/bjophthalmol-2014-305945","article-title":"Prevalence of corneal diseases in the rural Indian population: The Corneal Opacity Rural Epidemiological (CORE) study","volume":"99","author":"Gupta","year":"2015","journal-title":"Br J Ophthalmol"},{"key":"R6-20260422","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/bjo.68.1.13","article-title":"Posterior chamber intraocular lenses at the Wilmer Institute: A comparative analysis of complications and visual results","volume":"68","author":"Fagadau","year":"1984","journal-title":"Br J Ophthalmol"},{"key":"R7-20260422","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1600-0420.1997.tb00133.x","article-title":"Persisting corneal oedema following intracapsular cataract extraction","volume":"75","author":"Baggesen","year":"1997","journal-title":"Acta Ophthalmol Scand"},{"key":"R8-20260422","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1001\/archopht.1992.01080200117038","article-title":"National outcomes of cataract extraction. 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