{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:36:50Z","timestamp":1786739810176,"version":"build-2736575974"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>The study of papilledema with a novel noninvasive technique such as spectral domain-optical coherence tomography (SD-OCT) provides minute and detailed cross-sectional changes thus giving an insight into the application of biomechanical principles and pathophysiology of disc edema.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We measured average retinal nerve fiber layer (RNFL) thickness and the retinal pigment epithelium\/Bruch\u2019s membrane (RPE\/BM) angle at the temporal and nasal borders of the neural canal opening (NCO) in 30 eyes with papilledema, 30 eyes with papillitis, and 80 control eyes. The inward angulation was considered as positive and the outward as negative. Follow-up was done at 1, 2, 3, and 6 months. The main outcome measures are the average RNFL thickness and the RPE\/BM angle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      29 eyes (96.6%) with papilledema had a positive RPE\/BM angle (+8.11 \u00b1 3.13). 29 eyes (96.6%) with papillitis had a negative RPE\/BM angle (\u22121.04 \u00b1 3.27). On follow-up at 1 month, both RNFL thickness (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01) and RPE-BM angle (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001) reduced significantly in eyes with papilledema; in eyes with papillitis, there was a significant reduction in the RNFL thickness (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02), but not in the RPE-BM angle (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05). RNFL thickness in papilledema cases normalized at 3 months whereas RPE\/BM normalized at 6 months of follow-up. To detect papilledema, OCT has a sensitivity of 96.66% and specificity of 99.09% on both nasal and temporal sides.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>After appropriate treatment, the RPE\/BM angle in papilledema decreased much later than the RNFL thickness. Hence, the RPE\/BM angle in papilledema (positive) can be used to differentiate it from papillitis (negative) and also to monitor the activity of the disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_3269_20","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T23:07:16Z","timestamp":1630537636000},"page":"2372-2377","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Role of spectral domain optical coherence tomography in the diagnosis and prognosis of papilledema"],"prefix":"10.4103","volume":"69","author":[{"given":"Rakesh","family":"Panyala","sequence":"first","affiliation":[{"name":"Consultant Pediatric Ophthalmology and Strabismus, MaxiVision Eye Hospital, Karimnagar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Sharma","sequence":"additional","affiliation":[{"name":"Professor Head Strabismus, Pediatric Ophthalmology and Neuro-Ophthalmology, AIIMS, New Delhi, India"},{"name":"Director Strabismus Pediatric and Neuro-Ophthalmology Centre for Sight, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramanjit","family":"Sihota","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Saxena","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kameshwar","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Phuljhele","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sneha","family":"Gurrala","sequence":"additional","affiliation":[{"name":"MBBS, Kamineni Institute of Medical Sciences, Narketpally, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthika","family":"Bhaskaran","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"key":"B1-20240828","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/nm0995-970","article-title":"Optical biopsy and imaging using optical coherence tomography","volume":"1","author":"Fujimoto","year":"1995","journal-title":"Nat Med"},{"key":"B2-20240828","doi-asserted-by":"crossref","first-page":"6558","DOI":"10.1167\/iovs.10-6782","article-title":"Optical coherence tomography of the swollen optic nerve head:Deformation of the peripapillary retinal pigment epithelium layer in papilledema","volume":"52","author":"Kupersmith","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B3-20240828","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1167\/iovs.17-21592","article-title":"Quantitative association between peripapillary Bruch's membrane shape and intracranial pressure","volume":"58","author":"Gampa","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B4-20240828","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1001\/archopht.1977.04450090075006","article-title":"Optic disc edema in raised intracranial pressure","volume":"95","author":"Hayreh","year":"1977","journal-title":"V. 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