{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:58:06Z","timestamp":1787169486227,"version":"build-2736575974"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate long-term perimetric stabilization at set Target (IOPs) in primary angle-closure glaucoma with visual field defects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Two hundred forty-eight eyes, of 124 primary angle-closure glaucoma (PACG) patients on medical treatment, and 124 eyes, of 95 patients after trabeculectomy performed at least 5 years prior were evaluated. One hundred eighty-five eyes had a follow-up of \u226510 years. Target IOPs for mild, moderate, and severe glaucomatous optic neuropathy were set at \u226418, \u226415, and \u226412 mmHg, respectively. Progression was evaluated by event-based changes on guided progression analysis. Primary outcome measure was therapy required to achieve individualized Target IOP. Secondary outcome measure was assessment of perimetric change over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Mean baseline IOP was 23.34 \u00b1 6.16 mmHg in medically treated and 36.08 \u00b1 9.73 mmHg in surgically treated eyes (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0001). All eyes with a baseline IOP of &lt;25 mmHg were on medications alone, 65.33%, of those with a baseline IOP of 25\u201330 mmHg were on medications, while 34.67% required trabeculectomy. In total, 91.4% of eyes with a baseline IOP of &gt;30 mmHg underwent a trabeculectomy for achieving Target IOP. Perimetric stabilization was achieved in 98.17% of PACG eyes. \u201cTarget\u201d IOP was achieved for mild, moderate, and severe glaucomatous optic neuropathy, medically in 90.2, 73.9, and 29.7%, and surgery was required in 9.8, 26.1, and 70.3%, respectively. Overall analysis found that percentage reduction in IOP was significantly more after trabeculectomy than medical treatment, 64.16 \u00b1 14.91 and 43.61 \u00b1 13.73%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0001. Decrease in IOP was significantly greater 5\u20139 years after trabeculectomy, in comparison to \u226510 years,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Medications controlled IOP to \u201cTarget\u201d in PACG eyes with mild and moderate glaucoma for over \u226510 years, when the baseline IOP off treatment was &lt;30 mmHg. Trabeculectomy was necessary in PACG eyes having severe glaucomatous optic neuropathy, or with a baseline IOP of &gt;30 mmHg to achieve Target IOP. These appropriate initial therapeutic interventions and Target IOPs are therefore suggested as a clinically validated algorithm of care for different severities of PACG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ijo.ijo_329_21","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T11:42:39Z","timestamp":1633434159000},"page":"2721-2727","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Long-term perimetric stabilization with a management algorithm of set target intraocular pressure in different severities of primary angle-closure glaucoma"],"prefix":"10.4103","volume":"69","author":[{"given":"Ramanjit","family":"Sihota","sequence":"first","affiliation":[{"name":"Glaucoma Service, Dr Rajendra Prasad Centre for Ophthalmic Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti","family":"Shakrawal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay K","family":"Sharma","sequence":"additional","affiliation":[{"name":"Glaucoma Service, Dr Rajendra Prasad Centre for Ophthalmic Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amisha","family":"Gupta","sequence":"additional","affiliation":[{"name":"Glaucoma Service, Dr Rajendra Prasad Centre for Ophthalmic Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanuj","family":"Dada","sequence":"additional","affiliation":[{"name":"Glaucoma Service, Dr Rajendra Prasad Centre for Ophthalmic Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veena","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,9,25]]},"reference":[{"key":"B1-20240828","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"B2-20240828","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.4103\/0301-4738.73687","article-title":"An Indian perspective on primary angle closure and glaucoma","volume":"59","author":"Sihota","year":"2010","journal-title":"Indian J Ophthalmol"},{"key":"B3-20240828","doi-asserted-by":"crossref","first-page":"4519412","DOI":"10.1155\/2019\/4519412","article-title":"Selective laser trabeculoplasty protects glaucoma progression in the initial primary open-angle glaucoma and angle-closure glaucoma after laser peripheral iridotomy in the long term","volume":"2019","author":"Kurysheva","year":"2019","journal-title":"Biomed Res Int"},{"key":"B4-20240828","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1167\/iovs.18-25421","article-title":"Comparison of visual field progression rates among the high tension glaucoma, primary angle closure glaucoma, and normal tension glaucoma","volume":"60","author":"Ganeshrao","year":"2019","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"B5-20240828","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1016\/j.ophtha.2011.01.047","article-title":"Intraocular pressure control and long-term visual field loss in the Collaborative Initial Glaucoma Treatment Study","volume":"118","author":"Musch","year":"2011","journal-title":"Ophthalmology"},{"key":"B6-20240828","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0002-9394(00)00538-9","article-title":"The relationship between control of intraocular pressure and visual field deterioration. 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