{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:34:13Z","timestamp":1786649653381,"version":"build-2736575974"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,2]]},"abstract":"\n Purpose:<\/jats:title>\n To assess macular sensitivity and fixation pattern obtained by microperimetry and ganglion cell complex (GCC) obtained by optical coherence tomography (OCT) in cases with unilateral amblyopia and to compare with control.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n The study was conducted with 30 patients with amblyopia, aged 5\u201318 years, and 30 control eyes of healthy children in the same age group. Participants underwent full ophthalmological examination. Macular sensitivity, stabilization, and location of fixation values were measured using microperimetry. The GCC values were obtained by OCT. Measurements were compared between amblyopic eyes, fellow eyes, and controls. Any correlation between GCC, macular sensitivity, and fixation was investigated.\n P<\/jats:italic>\n < 0.05 was considered statistically significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The mean age was 10.13 \u00b1 3.49 years in the amblyopia group and 11.53 \u00b1 2.7 years in the control group. Three groups were formed: amblyopic eyes (Group 1,\n n<\/jats:italic>\n = 30), fellow eyes (Group 2,\n n<\/jats:italic>\n = 30), and control eyes (Group 3,\n n<\/jats:italic>\n = 30). The macular sensitivity values were found highest in the control group (\n P<\/jats:italic>\n = 0.007). Bivariate contour ellipse area 1, which is the numerical value of fixation stabilization, was measured to be the lowest in the control group (\n P<\/jats:italic>\n < 0.0001). In the analysis among the three groups, no significant difference was observed in terms of the GCC (\n P<\/jats:italic>\n = 0.229). In the correlation analyses, a significant correlation was detected between macular sensitivity and GCC values in amblyopic eyes.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n In amblyopic eyes, the macular sensitivity was significantly lower and the GCC thickness was found to be in a positive correlation with macular sensitivity.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ijo.ijo_3382_22","type":"journal-article","created":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T03:00:09Z","timestamp":1706238009000},"page":"232-235","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of the macular sensitivity and retinal ganglion cell layer in unilateral amblyopia"],"prefix":"10.4103","volume":"72","author":[{"given":"Nilay","family":"\u00c7i\u00e7ek","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Corlu State Hospital, Tekirda\u011f"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengi","family":"Demirayak","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Health Sciences, Bak\u0131rk\u00f6y Dr. Sadi Konuk Training and Research Hospital, \u0130stanbul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadime U","family":"Yigit","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hali\u00e7 University, \u0130stanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,1,25]]},"reference":[{"key":"R1-20260428","first-page":"1704","article-title":"Amblyopia: A multidisciplinary approach. Proctor lecture","volume":"26","author":"Von Noorden","year":"1985","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R2-20260428","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1167\/iovs.09-3931","article-title":"Decreased gray matter concentration in the lateral geniculate nuclei in human amblyopes","volume":"51","author":"Barnes","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R3-20260428","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1152\/jn.01060.2009","article-title":"The amblyopic deficit and its relationship to geniculo-cortical processing streams","volume":"104","author":"Hess","year":"2010","journal-title":"J Neurophysiol"},{"key":"R4-20260428","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1016\/j.ophtha.2009.03.013","article-title":"Macular and nerve fiber layer thickness in amblyopia: The Sydney Childhood Eye Study","volume":"116","author":"Huynh","year":"2009","journal-title":"Ophthalmology"},{"key":"R5-20260428","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3928\/01913913-20130319-02","article-title":"Macular and retinal nerve fiber layer thickness in unilateral anisometropic or strabismic amblyopia","volume":"50","author":"Andalib","year":"2013","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"R6-20260428","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3928\/01913913-20050701-03","article-title":"Thickness of the retinal nerve fiber layer, macular thickness and macular volume in patients with strabismic amblyopia","volume":"42","author":"Altintas","year":"2005","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"R7-20260428","doi-asserted-by":"crossref","first-page":"802","DOI":"10.3109\/02713683.2013.779721","article-title":"The morpho-functional evaluation of retina in amblyopia","volume":"38","author":"Tugcu","year":"2013","journal-title":"Curr Eye Res"},{"key":"R8-20260428","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jaapos.2011.09.011","article-title":"Measurement of retinal nerve fiber layer thickness, macular thickness, and foveal volume in amblyopic eyes using spectral-domain optical coherence tomography","volume":"16","author":"Dickmann","year":"2012","journal-title":"J AAPOS"},{"key":"R9-20260428","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1080\/08820538.2017.1375125","article-title":"Current clinical application of microperimetry: A review","volume":"33","author":"Molina-Mart\u00edn","year":"2018","journal-title":"Semin Ophthalmol"},{"key":"R10-20260428","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.jaapos.2011.03.019","article-title":"A morphofunctional study of amblyopic eyes with the use of optical coherence tomography and microperimetry","volume":"15","author":"Dickmann","year":"2011","journal-title":"J AAPOS"},{"key":"R11-20260428","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1016\/S0161-6420(02)01120-X","article-title":"Patient selection for macular translocation surgery using the scanning laser ophthalmoscope","volume":"109","author":"Fujii","year":"2002","journal-title":"Ophthalmology"},{"key":"R12-20260428","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1097\/IAE.0b013e318196bd65","article-title":"Fixation stability measurement using the MP1 microperimeter","volume":"29","author":"Crossland","year":"2009","journal-title":"Retina"},{"key":"R13-20260428","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3928\/01913913-20200428-01","article-title":"Retinal sensitivity and fixation analysis using microperimetry in children with anisometropic amblyopia","volume":"57","author":"Dikkaya","year":"2020","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"R14-20260428","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3109\/08820538.2015.1123739","article-title":"Fixation characteristics of severe amblyopia subtypes: Which one is worse?","volume":"32","author":"Koylu","year":"2017","journal-title":"Semin Ophthalmol"},{"key":"R15-20260428","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1167\/iovs.12-11054","article-title":"A quantitative study of fixation stability in amblyopia","volume":"54","author":"Subramanian","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R16-20260428","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/cne.902330403","article-title":"Development of the human retina: Patterns of cell distribution and redistribution in the ganglion cell layer","volume":"233","author":"Provis","year":"1985","journal-title":"J Comp Neurol"}],"container-title":["Indian Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_3382_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:56:34Z","timestamp":1786647394000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/IJO.IJO_3382_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,25]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ijo.ijo_3382_22","relation":{},"ISSN":["0301-4738","1998-3689"],"issn-type":[{"value":"0301-4738","type":"print"},{"value":"1998-3689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,25]]},"assertion":[{"value":"2022-12-28","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-04","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}